Journal
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
Volume 126, Issue 6, Pages 613-622Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.anai.2021.02.009
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Funding
- National Institute of Arthritis and Musculoskeletal and Skin Diseases/National Institutes of Health [1U01AR077511]
- National Institutes of Health/National Cancer Institute Cancer Center Support Grant [P30 CA008748]
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This article provides an overview of the most common cutaneous adverse events caused by immune checkpoint inhibitors, including their grading and treatment, aiming to help healthcare professionals identify and manage these issues effectively.
Objective: To familiarize the reader with the most common cutaneous adverse events with immune checkpoint inhibitors (CPIs) and their grading and treatment. Data Sources: Recent research articles, relevant review articles, and case series/reports in English from the PubMed database mostly, from 2010 onward. Study Selections: Most data are from retrospective studies and case series. Older studies regarding the mechanism were included if they were of particular importance. Results: An understanding of this review should enable the reader to identify specific skin disorders in patients receiving immune CPIs, grade the adverse event, and be able to treat or refer the patient as needed. Conclusion: Allergists/immunologists need to be familiar with these immune-related cutaneous adverse events because their incidence will increase with the ever-expanding use of CPIs and, in particular, because patients will certainly continue to be referred suspecting drug allergies. (c) 2021 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
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