Gastrointestinal immunopathology of food protein-induced enterocolitis syndrome and other non-immunoglobulin E-mediated food allergic diseases

Objective: To provide a concise summary of the current literature regarding gastrointestinal immunopathology of food protein-induced enterocolitis syndrome (FPIES) and other non-immunoglobulin E (IgE)-mediated food allergic diseases. Data Sources: Data were extracted from PubMed, MEDLINE, and ScienceDirect databases. Study Selections: Original articles, review articles, and guidelines published in the past 5 years in peer reviewed journals were first summarized. The original articles cited were then reviewed and relevant results were extracted. Results: Patients with FPIES and non-IgE-mediated food allergic diseases developed vomiting, diarrhea, and food aversion expelled food allergen from their bodies. Aside from T helper type 2 (TH2) immunity, TH1, TH17, innate immunity, and epithelial mucosal barrier defect were also found to be important in the pathogenesis. Eosinophils, widely identified in the biopsy samples, were key players or were late-recruited cells for tissue repairs in those diseases. Intestinal dysbiosis and their metabolites stimulated enterochromaffin cells or enteroendocrine cells to produce serotonin, interfering with intestinal motility and subsequently affecting brain function. FPIES and non-IgE-mediated food allergic diseases were likely part of the atopic march. Allergic inflammation in intestinal mucosa might result in subsequent inflammation in the airway mucosa, suggesting the theory of one mucosa, one disease. Conclusion: The immune responses of FPIES and non-IgE-mediated food allergic diseases were not limited to the gastrointestinal tract, but also trigger wider inflammatory responses beyond it. Further research will be required to determine the systemic effect and intestinal microbiome of those diseases. (C) 2021 Published by Elsevier Inc. on behalf of American College of Allergy, Asthma & Immunology.

Automated summary

The study provides a concise summary of the current literature on gastrointestinal immunopathology of FPIES and non-IgE-mediated food allergic diseases, revealing the complex pathogenesis involving various immune responses, intestinal dysbiosis, and other factors. Further research is needed to determine the systemic effects and intestinal microbiome of these diseases.