Journal
ANNALS ACADEMY OF MEDICINE SINGAPORE
Volume 50, Issue 2, Pages -Publisher
ACAD MEDICINE SINGAPORE
DOI: 10.47102/annals-acadmedsg.2020144
Keywords
Atopic dermatitis; extrinsic eczema; intrinsic eczema
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Recent research on atopic dermatitis has identified it as a heterogeneous inflammatory skin disorder with different immune polarisation and genetic mutations, leading to the development of endotype-driven management. A practical approach has been proposed to classify patients into intrinsic and extrinsic phenotypes for targeted management based on underlying endotypes.
Recent research in atopic dermatitis (AD) has identified it to be a heterogeneous inflammatory skin disorder of different endotypes (immune polarisation of T- cell subsets and genetic mutations) underlying various phenotypes (age of onset, ethnicity, disease severity, etc.). The corresponding heterogeneity in underlying patho- mechanisms of the disease has resulted in an impetus towards an endotype-driven management of AD. We propose a practical approach that is based on classifying AD patients into intrinsic and extrinsic phenotypes and their corresponding underlying endotypes. This approach aims to provide a practical method that integrates recent understanding of AD pathogenesis for a targeted endotype-driven management of AD.
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