Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 18, Pages 10409-10414Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202101682
Keywords
cross-coupling; diacetates; organozinc reagents; transition-metal-free; triarylmethane and 1; 1-diarylalkane
Categories
Funding
- Deutsche Forschungsgemeinschaft (DFG)
- Cluster of Excellence e-conversion
- Projekt DEAL
Ask authors/readers for more resources
A variety of functionalized triarylmethane and 1,1-diarylalkane derivatives were successfully synthesized via a transition-metal-free, one-pot, two-step procedure, demonstrating the synthetic utility of the method for biologically relevant molecules. The sequential cross-coupling enabled by changing the solvent from THF to toluene and the proposed S(N)1-type mechanism were supported by experimental studies. The method was further demonstrated by the synthesis of several biologically relevant molecules, including an anti-tuberculosis agent, an anti-breast cancer agent, a precursor of a sphingosine-1-phosphate (S1P) receptor modulator, and a FLAP inhibitor.
A variety of functionalized triarylmethane and 1,1-diarylalkane derivatives were prepared via a transition-metal-free, one-pot and two-step procedure, involving the reaction of various benzal diacetates with organozinc reagents. A sequential cross-coupling is enabled by changing the solvent from THF to toluene, and a two-step S(N)1-type mechanism was proposed and evidenced by experimental studies. The synthetic utility of the method is further demonstrated by the synthesis of several biologically relevant molecules, such as an anti-tuberculosis agent, an anti-breast cancer agent, a precursor of a sphingosine-1-phosphate (S1P) receptor modulator, and a FLAP inhibitor.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available