Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 13, Pages 6965-6969Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202100164
Keywords
carbon nitrides; C− H activation; chromoselectivity; photobiocatalysis; unspecific peroxygenases
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Funding
- European Unions Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant [764920]
- Austrian Science Fund (FWF) [DOC 46-B21]
- University of Graz
- Field of Excellence BioHealth
- Max-Planck Society
- German Chemical Industry Fund (Liebig Fellowship, Fonds der Chemischen Industrie, FCI)
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germanys Excellence Strategy [EXC 2008-390540038-UniSysCat]
- Centre of Excellence for Biocatalysis, Biotransformations and Biomanufacture (CoEBio3)
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The redox potential of a carbon nitride photocatalyst can be tuned by changing the irradiation wavelength, enabling selective generation of enantiomers of phenylethanol through photo-chemo-enzymatic cascades. Green light irradiation leads to (R)-1-phenylethanol, while blue light irradiation results in (S)-1-phenylethanol.
Controlling the selectivity of a chemical reaction with external stimuli is common in thermal processes, but rare in visible-light photocatalysis. Here we show that the redox potential of a carbon nitride photocatalyst (CN-OA-m) can be tuned by changing the irradiation wavelength to generate electron holes with different oxidation potentials. This tuning was the key to realizing photo-chemo-enzymatic cascades that give either the (S)- or the (R)-enantiomer of phenylethanol. In combination with an unspecific peroxygenase from Agrocybe aegerita, green light irradiation of CN-OA-m led to the enantioselective hydroxylation of ethylbenzene to (R)-1-phenylethanol (99 % ee). In contrast, blue light irradiation triggered the photocatalytic oxidation of ethylbenzene to acetophenone, which in turn was enantioselectively reduced with an alcohol dehydrogenase from Rhodococcus ruber to form (S)-1-phenylethanol (93 % ee).
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