Journal
ANALYTICA CHIMICA ACTA
Volume 1147, Issue -, Pages 155-164Publisher
ELSEVIER
DOI: 10.1016/j.aca.2020.12.058
Keywords
Enantioselective recognition; Polyaniline; Electrochemical sensor; Tryptophan
Categories
Funding
- National Natural Science Foundation of China [21775046, 21635003, 21675055]
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Chiral nanomaterials are still a challenge in achieving effective enantioselective recognition in the field of chemistry and biology. Through the synthesis of left- and right-handed polyaniline, this study successfully constructed electrochemical chiral sensors for discrimination of tryptophan isomers, showing high enantioselectivity.
Effective enantioselective recognition with chiral nanomaterials remains a challenge in the field of chemistry and biology. In this paper, a pair of left- and right-handed polyaniline (defined as S-PANI and R-PANI) were synthesized by chemical oxidation of aniline to form a specially twisted nanoribbon, which was induced by enantiomeric camphorsulfonic acid. Both S-PANI and R-PANI were used to construct electrochemical chiral sensors for the discrimination of tryptophan isomers (D- and L-Trp). Owing to the formation of efficient chiral nanospace with special nanoribbon morphology and enormous amounts of oxygen-containing functional groups of S-PANI or R-PANI, the high enantioselectivity was obtained with the recognition efficiency of 4.90 (D-Trp) on S-PANI and 4.20 (L-Trp) on R-PANI, respectively. The obtained chiral electrodes were also used for the determination of the enantiomeric excess (ee) for Trp, and a good linear relationship between peak currents and ee% of Trp was obtained. Furthermore, the strategy we proposed has tremendous potential in enantiomer recognition field. (C) 2021 Elsevier B.V. All rights reserved.
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