4.6 Article

Consensus conference on heart-kidney transplantation

Journal

AMERICAN JOURNAL OF TRANSPLANTATION
Volume 21, Issue 7, Pages 2459-2467

Publisher

WILEY
DOI: 10.1111/ajt.16512

Keywords

clinical research; practice; ethics; ethics and public policy; heart disease; heart transplantation; cardiology; immunosuppressant; kidney disease; kidney transplantation; nephrology

Funding

  1. California Heart Center Foundation, Los Angeles California

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Simultaneous heart-kidney transplant has achieved successful outcomes for patients with end-stage heart disease and concomitant kidney disease, but decision-making for this procedure presents challenges. A consensus conference in 2019 aimed to develop interdisciplinary criteria, evaluate kidney allocation, and recommend standardized care for sHK recipients.
Simultaneous heart-kidney transplant (sHK) has enabled the successful transplantation of patients with end-stage heart disease and concomitant kidney disease, with non-inferior outcomes to heart transplant (HT) alone. The decision for sHK is challenged by difficulties in differentiating those patients with a significant component of reversible kidney injury due to cardiorenal syndrome who may recover kidney function after HT, from those with intrinsic advanced kidney disease who would benefit most from sHK. A consensus conference on sHK took place on June 1, 2019 in Boston, Massachusetts. The conference represented a collaborative effort by experts in cardiothoracic and kidney transplantation from centers across the United States to explore the development of guidelines for the interdisciplinary criteria for kidney transplantation in the sHK candidate, to evaluate the current allocation of kidneys to follow the heart for sHK, and to recommend standardized care for the management of sHK recipients. The conference served as a forum to unify criteria between the different specialties and to forge a pathway for patients who may need dual organ transplantation. Due to the continuing shortage of available donor organs, ethical problems related to multi-organ transplantation were also debated. The findings and consensus statements are presented.

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