Correlation between ASPECTS and Core Volume on CT Perfusion: Impact of Time since Stroke Onset and Presence of Large-Vessel Occlusion

BACKGROUND AND PURPOSE: Both ASPECTS and core volume on CTP are used to estimate infarct volume in acute ischemic stroke. To evaluate the potential role of ASPECTS for acute endovascular treatment decisions, we studied the correlation between ASPECTS and CTP core, depending on the timing and the presence of large-vessel occlusion. MATERIALS AND METHODS: We retrospectively reviewed all MCA acute ischemic strokes with standardized reconstructions of CTP maps entered in the Acute STroke Registry and Analysis of Lausanne (ASTRAL) registry. Correlation between ASPECTS and CTP core was determined for early (<6 hours) versus late (6?24 hours) times from stroke onset and in the presence versus absence of large-vessel occlusion. We used correlation coefficients and adjusted multiple linear regression models. RESULTS: We included 1046 patients with a median age of 71.4?years (interquartile range, IQR?= 59.8?79.4 years), an NIHSS score of 12 (IQR, 6?18), an ASPECTS of 9 (IQR, 7?10), and a CTP core of 13.6?mL (IQR, 0.6?52.8 mL). The overall correlation between ASPECTS and CTP core was moderate (? = ?0.49, P?

Automated summary

This study evaluated the potential role of ASPECTS in acute endovascular treatment decisions and found a moderate correlation between ASPECTS and CTP core. The results showed that the correlation between ASPECTS and CTP core varied depending on the timing and the presence of large-vessel occlusion.