Journal
AMERICAN JOURNAL OF CHINESE MEDICINE
Volume 49, Issue 2, Pages 315-358Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0192415X21500166
Keywords
Inula Species; Phytochemical Constituent; Biosynthesis; Biological Activity; Review
Funding
- National Natural Science Foundation of China [82003923, 81930112, 81703769]
- National Key Research and Development -Program of China [2018YFC1705900]
- Dalian Science and Technology Leading Talents Project [2019RD15]
- Liaoning Provincial Key Research and Development Program [2019JH2/10300022]
- Natural Science Foundation of Liaoning Province [2020-BS-203, 2020-MS-256]
- Dalian Young Star of Science and Technology [2019RQ123]
- Distinguished professor of Liaoning Province
- Liaoning - Revitalization Talents Program
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Inula, a genus of the Asteraceae, is rich in secondary metabolites with pharmacological activities, which have potential applications in drug development for various diseases. Recent researches from 2010 to 2020 have provided scientific basis and support for the utilization of Inula in new drug development.
As a genus of the Asteraceae, Inula is widely distributed all over the world, and several of them are being used in traditional medicines. A number of metabolites were isolated from Inula species, and some of these have shown to possess ranges of pharmacological activities. The genus Inula contains abundant sesquiterpenoids, such as eudesmanes, xanthanes, and sesquiterpenoid dimers and trimers. In addition, other types of terpenoids, flavonoids, and lignins also exist in the genus Inula. Since 2010, more than 300 new secondary metabolites, including several known natural products that were isolated for the first time from the genus Inula. Most of them exhibited potential bioactivities in various diseases. The review aimed to summarize the advance of recent researches (2010-2020) on phytochemical constituents, biosynthesis, and pharmacological properties of the genus Inula for providing a scientific basis and supporting its application and exploitation for new drug development.
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