Related references
Note: Only part of the references are listed.Thermodynamics of Prebiotic Phosphorylation
Matthew A. Pasek
CHEMICAL REVIEWS (2020)
Applications of fluorine-containing amino acids for drug design
Haibo Mei et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Synergistic Photoredox/Transition-Metal Catalysis for Carbon-Carbon Bond Formation Reactions
Maxime De Abreu et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2020)
Phosphorus-Containing Fluoropolymers: State of the Art and Applications
Mohammad Wehbi et al.
ACS APPLIED MATERIALS & INTERFACES (2020)
S-(Diethyl phosphonodifluoromethyl)Benzenesulfonothioate: A New Reagent for the Synthesis of SCF2PO(OEt)2-containing Molecules
Fabien Petit-Cancelier et al.
ADVANCED SYNTHESIS & CATALYSIS (2020)
C-P Natural Products as Next-Generation Herbicides: Chemistry and Biology of Glufosinate
Chengzeng Zhou et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)
Visible Light-Promoted Phosphine-Catalyzed Difluoroalkylation of Arenes and Heterocycles
Heng Lu et al.
JOURNAL OF ORGANIC CHEMISTRY (2020)
Kinetically Controlled Radical Addition/Elimination Cascade: From Alkynyl Aziridine to Fluorinated Allenes
Tingting Song et al.
ORGANIC LETTERS (2020)
Cu2O-catalyzed phosphonyldifluoromethylation of allylic alcohols through a radical 1,2-aryl migration
Liangzhen Hu et al.
TETRAHEDRON (2020)
Chemistry glows green with photoredox catalysis
Giacomo E. M. Crisenza et al.
NATURE COMMUNICATIONS (2020)
Copper-based fluorinated reagents for the synthesis of CF2R-containing molecules (R ≠ F)
Louise Ruyet et al.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2020)
Tailor-Made Amino Acids and Fluorinated Motifs as Prominent Traits in Modern Pharmaceuticals
Haibo Mei et al.
CHEMISTRY-A EUROPEAN JOURNAL (2020)
Fluorine-containing drugs approved by the FDA in 2019
Haibo Mei et al.
CHINESE CHEMICAL LETTERS (2020)
Regio- and Enantioselective Bromocyclization of Difluoroalkenes as a Strategy to Access Tetrasubstituted Difluoromethylene-Containing Stereocenters
Edward Miller et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
Richard T. Eastman et al.
ACS CENTRAL SCIENCE (2020)
Contribution of Organofluorine Compounds to Pharmaceuticals
Munenori Inoue et al.
ACS OMEGA (2020)
Fluorocarbon Refrigerants and their Syntheses: Past to Present
Alexandre J. Sicard et al.
CHEMICAL REVIEWS (2020)
Current Contributions of Organofluorine Compounds to the Agrochemical Industry
Yuta Ogawa et al.
ISCIENCE (2020)
Metabolic Efficacy of Phosphate Prodrugs and the Remdesivir Paradigm
Andrew J. Wiemer
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2020)
Next generation organofluorine containing blockbuster drugs
Jianlin Han et al.
JOURNAL OF FLUORINE CHEMISTRY (2020)
Enantioselective Lewis base catalyzed phosphonyldifluoromethylation of allylic fluorides using a C-silyl latent pronucleophile
You Zi et al.
CHEMICAL COMMUNICATIONS (2020)
Nickel-Catalyzed Carbofluoroalkylation of 1,3-Enynes to Access Structurally Diverse Fluoroalkylated Allenes
Kai-Fan Zhang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)
Natural Products Containing 'Rare' Organophosphorus Functional Groups
Janusz J. Petkowski et al.
MOLECULES (2019)
Siladifluoromethylation and Deoxo-trifluoromethylation of PV-H Compounds with TMSCF3: Route to PV-CF2- Transfer Reagents and P-CF3 Compounds
Vinayak Krishnamurti et al.
ORGANIC LETTERS (2019)
Synthetic Phosphonic Acids as Potent Tools to Study Phosphonate Enzymology
K. Pallitsch et al.
SYNLETT (2019)
An Intrinsic Hydrophobicity Scale for Amino Acids and Its Application to Fluorinated Compounds
Waldemar Hoffmann et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)
Fluorine-Containing Drugs Approved by the FDA in 2018
Haibo Mei et al.
CHEMISTRY-A EUROPEAN JOURNAL (2019)
Photoinduced Nonstabilized Azomethine Ylide Formation for the Preparation of Fluorine Containing Pyrrolidines
Thibault Thierry et al.
JOURNAL OF ORGANIC CHEMISTRY (2019)
ORGANIC CHEMISTRY Copper's rapid ascent in visible-light photoredox catalysis
Asik Hossain et al.
SCIENCE (2019)
Solvent-Promoted Catalyst-Free Nucleophilic Fluoroalkylation of Aldehydes
Kazuki Komoda et al.
CHEMISTRYSELECT (2019)
Synthesis of (Difluoromethyl)cycloalkenes from 2-Cycloalkenones by Utilizing Phospha-Brook Rearrangement
Yoshihiko Yamamoto et al.
ADVANCED SYNTHESIS & CATALYSIS (2019)
α-Heteroatom-substituted gem-Bisphosphonates: Advances in the Synthesis Prospects for Biomedical Application
Vadim D. Romanenko
CURRENT ORGANIC CHEMISTRY (2019)
Palladium-Catalyzed Asymmetric Allylic Fluoroalkylation/Trifluoromethylation
Barry M. Trost et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Difluorophosphonylated Allylic Ether Moiety as a 2′-Modification of RNA-Type Molecules: Synthesis, Thermal, and Metabolic Studies
Emmanuel Pfund et al.
ORGANIC LETTERS (2019)
Metal-Free Visible-Light-Induced Construction of Difluoro-Containing Dibenzazepines
Dan Liu et al.
ORGANIC LETTERS (2019)
Organophotoredox-Catalyzed C(sp2)-H Difluoromethylenephosphonation of Imidazoheterocycles
Mukta Singsardar et al.
ORGANIC LETTERS (2019)
Synthesis, Derivatization, and Structural Analysis of Phosphorylated Mono-, Di-, and Trifluorinated D-Gluco-heptuloses by Glucokinase: Tunable Phosphoglucomutase Inhibition
Jian-She Zhu et al.
ACS OMEGA (2019)
The self-disproportionation of enantiomers (SDE) via column chromatography of β-amino-α,α-difluorophosphonic acid derivatives
Magdalena Kwiatkowska et al.
AMINO ACIDS (2019)
Phosphonate prodrugs: an overview and recent advances
Kenneth M. Heidel et al.
FUTURE MEDICINAL CHEMISTRY (2019)
Three-Component Ruthenium-Catalyzed Direct Meta-Selective C-H Activation of Arenes: A New Approach to the Alkylarylation of Alkenes
Xin-Gang Wang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Copper-Mediated Synthesis of (Diethylphosphono) difluoromethyl Thioethers from Diazonium Salts, NaSCN, and TMS-CF2PO(OEt)2
Yang Ou et al.
ASIAN JOURNAL OF ORGANIC CHEMISTRY (2019)
Phosphorus - Friend of the Medicinal Chemist
Jonathan Hall
CHIMIA (2019)
Rapid Entry into Biologically Relevant α,α-Difluoroalkylphosphonates Bearing Allyl Protection Deblocking under Ru(II)/(IV)-Catalysis
Kaushik Panigrahi et al.
ORGANIC LETTERS (2019)
Synthesis of fluoroalkylated alkynes via visible-light photocatalysis
Naila Iqbal et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2019)
Benzothiazolines as radical transfer reagents: hydroalkylation and hydroacylation of alkenes by radical generation under photoirradiation conditions
Tatsuhiro Uchikura et al.
CHEMICAL COMMUNICATIONS (2019)
Photoinduced synthesis of fluorinated dibenz[b,e]azepines via radical triggered cyclization
Xu-Kuan Qi et al.
CHEMICAL COMMUNICATIONS (2019)
The intriguing biology and chemistry of fosfomycin: the only marketed phosphonate antibiotic
Yingying Cao et al.
RSC ADVANCES (2019)
How Prebiotic Chemistry and Early Life Chose Phosphate
Ziwei Liu et al.
LIFE-BASEL (2019)
Visible-light-mediated difluoromethylphosphonation of alkenes for the synthesis of CF2P-containing heterocycles
Qiang Yang et al.
ORGANIC CHEMISTRY FRONTIERS (2019)
BiCl3-Mediated direct functionalization of unsaturated C-C bonds with an electrophilic SCF2PO(OEt)2 reagent
Jianjun Wang et al.
CHEMICAL COMMUNICATIONS (2019)
SYNTHESIS OF γ-DIFLUOROMETHYLATED TETRONATE DERIVATIVES FROM SQUARATES USING DIFLUOROMETHYLPHOSPHONATE
Yoshihiko Yamamoto et al.
HETEROCYCLES (2019)
Oxy-Difluoroalkylation of Allylamines with CO2 via Visible-Light Photoredox Catalysis
Zhu-Bao Yin et al.
ORGANIC LETTERS (2018)
Radical Allylation:E-Selective Radical Conjugate Addition-Elimination Reaction from Morita-Baylis-Hillman Adducts
Cyril Lebargy et al.
SYNLETT (2018)
Palladium-Catalyzed Synthesis of Aryl and Heteroaryl Difluoromethylated Phosphonates
Maria V. Ivanova et al.
SYNTHESIS-STUTTGART (2018)
Mapping Functional Substrate-Enzyme Interactions in the pol β Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs
Vinod K. Batra et al.
BIOCHEMISTRY (2018)
Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State
Keriann Oertell et al.
BIOCHEMISTRY (2018)
1-C-phosphonomethyl- and 1-C-difluorophosphonomethyl-1,4-imino-L-arabinitols as Galf transferase inhibitors: A comparison
Chloe Cocaud et al.
CARBOHYDRATE RESEARCH (2018)
Visible-light induced three-component alkynyl-difluoroalkylation of unactivated alkenes
Weiwei Jin et al.
CHEMICAL COMMUNICATIONS (2018)
Modern Approaches for Asymmetric Construction of Carbon-Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs
Yi Zhu et al.
CHEMICAL REVIEWS (2018)
Photocatalyzed Intermolecular Aminodifluoromethylphosphonation of Alkenes: Facile Synthesis of α,α-Difluoro-γ- aminophosphonates
Qiang Yang et al.
CHEMISTRY-A EUROPEAN JOURNAL (2018)
Synthesis and Biological Activity of Novel Fluorinated Amide Hydroxy Methyl Coumarin Derivatives
Lili Qiao et al.
CHINESE JOURNAL OF ORGANIC CHEMISTRY (2018)
Sustainable Radical Cascades to Synthesize Difluoroalkylated Pyrrolo[1,2-a]indoles
Honggui Huang et al.
JOURNAL OF ORGANIC CHEMISTRY (2018)
Synthesis and Evaluation of Fluoroalkyl Phosphonyl Analogues of 2-C-Methylerythritol Phosphate as Substrates and Inhibitors of IspD from Human Pathogens
David Bartee et al.
JOURNAL OF ORGANIC CHEMISTRY (2018)
Hydrophosphonodifluoromethylation of Alkenes via Thiyl-Radical/Photoredox Catalysis
Wenhao Huang et al.
JOURNAL OF ORGANIC CHEMISTRY (2018)
Visible-Light Photocatalytic Difluoroalkylation-Induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow
Xiao-Jing Wei et al.
JOURNAL OF ORGANIC CHEMISTRY (2018)
Synthesis of α,α-Difluorinated Phosphonate pSer/pThr Mimetics via Rhodium-Catalyzed Asymmetric Hydrogenation of β-Difluorophosphonomethyl α-(Acylamino)acrylates
Hong-Xue Chen et al.
ORGANIC LETTERS (2018)
Zn(II) Byproduct Enhances the Cu-Catalyzed Cross-Coupling of Bromozinc Difluorophosphonate with lodobenzoates: A DFT Study
Jesus Jover
ORGANOMETALLICS (2018)
CuX2-mediated halocyclization of 1,1-difluoro-2,3-allenylphosphonic acid monoesters -synthesis of novel cyclic phosphate mimics
Xu Jiang et al.
TETRAHEDRON (2018)
Stereoselective cobalt-catalyzed halofluoroalkylation of alkynes
Guojiao Wu et al.
CHEMICAL SCIENCE (2018)
Transition-Metal (Cu, Pd, Ni)-Catalyzed Difluoroalkylation via Cross-Coupling with Difluoroalkyl Halides
Zhang Feng et al.
ACCOUNTS OF CHEMICAL RESEARCH (2018)
Visible-Light-Induced Difluoropropargylation Reaction with Benzothiazoline as a Reductant
Jingzhi Chen et al.
ADVANCED SYNTHESIS & CATALYSIS (2018)
Copper-Promoted Cross-Coupling Reactions for the Synthesis of Aryl(difluoromethyl)phosphonates Using Trimethylsilyl(difluoromethyl)phosphonate
Kazuki Komoda et al.
MOLECULES (2018)
Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism
Christopher T. Walsh et al.
CHEMICAL REVIEWS (2018)
Phosphonate analogues of nucleoside polyphosphates
Vadim D. Romanenko et al.
ARKIVOC (2018)
Drugging the Undruggable: Therapeutic Potential of Targeting Protein Tyrosine Phosphatases
Zhong-Yin Zhang
ACCOUNTS OF CHEMICAL RESEARCH (2017)
Phosphonate Biochemistry
Geoff P. Horsman et al.
CHEMICAL REVIEWS (2017)
Solid-State Structure of a Bromo(difluoromethylenephosphonato)cuprate - a Key Intermediate for the Synthesis of α,α-Difluoromethylenephosphonates
Christian Alter et al.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (2017)
β-Amino-γ,γ-difluoro-ω-phosphonoglutamic Acid Derivatives: An Unexplored, Multifaceted Structural Type of Tailor-Made α-Amino Acids
Wenzhong Zhang et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2017)
Copper-Mediated [(Diethylphosphono)difluoromethyl]thiolation of α-Bromo Ketones
Maria V. Ivanova et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2017)
Photoredox-Catalyzed Cascade Difluoroalkylation and Intramolecular Cyclization for Construction of Fluorinated γ-Butyrolactones
Wanxing Sha et al.
JOURNAL OF ORGANIC CHEMISTRY (2017)
Tunable Approach for the Stereoselective Synthesis of 1-C-Diethylphosphono(difluoromethyl) Iminosugars as Glycosyl Phosphate Mimics
Chloe Cocaud et al.
JOURNAL OF ORGANIC CHEMISTRY (2017)
Chemical Stabilization of Unnatural Nucleotide Triphosphates for the in Vivo Expansion of the Genetic Alphabet
Aaron W. Feldman et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
α,α-Difluoro-β-iminophosphonates, an alternative strategy towards the synthesis of α,α-difluoro-β-aminophosphonate derivatives
M. Z. Szewczyk et al.
NEW JOURNAL OF CHEMISTRY (2017)
mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation
Anna M. Rydzik et al.
NUCLEIC ACIDS RESEARCH (2017)
Latest achievements in the preparation of fluorinated aminophosphonates and aminophosphonic acids
Tomasz Cytlak et al.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS (2017)
Exploring allene chemistry using phosphorus-based allenes as scaffolds
K. C. Kumara Swamy et al.
PURE AND APPLIED CHEMISTRY (2017)
Silicon-Based Reagents for Difluoromethylation and Difluoromethylenation Reactions
Sankarganesh Krishnamoorthy et al.
SYNTHESIS-STUTTGART (2017)
A practical and scalable system for heteroaryl amino acid synthesis
R. A. Aycock et al.
CHEMICAL SCIENCE (2017)
Copper-Mediated Introduction of the CF2PO(OEt)2 Motif: Scopeand Limitations
Maria V. Ivanova et al.
CHEMISTRY-A EUROPEAN JOURNAL (2017)
Benzyl Mono-P-Fluorophosphonate and Benzyl Penta-P-Fluorophosphate Anions Are Physiologically Stable Phosphotyrosine Mimetics and Inhibitors of Protein Tyrosine Phosphatases
Stefan Wagner et al.
CHEMISTRY-A EUROPEAN JOURNAL (2017)
A Chemist's Perspective on the Role of Phosphorus at the Origins of Life
Christian Fernandez-Garcia et al.
LIFE-BASEL (2017)
Phosphonodifluoropyruvate is a mechanism-based inhibitor of phosphonopyruvate decarboxylase from Bacteroides fragilis
Katharina Pallitsch et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2017)
Carbonylation of Difluoroalkyl Bromides Catalyzed by Palladium
Hai-Yang Zhao et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Copper Salt-Controlled Divergent Reactivity of [Cu]CF2PO(OEt)2 with α-Diazocarbonyl Derivatives
Maria V. Ivanova et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
An Electrophilic Reagent for the Direct Introduction of the SCF2PO(OEt)2 Group to Molecules
Heng-Ying Xiong et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Tandem Difluoroalkylation-Arylation of Enamides Catalyzed by Nickel
Ji-Wei Gu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Gold-Catalyzed Highly Selective Photoredox C(sp2)-H Difluoroalkylation and Perfluoroalkylation of Hydrazones
Jin Xie et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
Yu Zhou et al.
CHEMICAL REVIEWS (2016)
Organic Photoredox Catalysis
Nathan A. Romero et al.
CHEMICAL REVIEWS (2016)
New Prospects toward the Synthesis of Difluoromethylated Phosphate Mimics
Maria V. Ivanova et al.
CHEMISTRY-A EUROPEAN JOURNAL (2016)
New Chiral Reagent for Installation of Pharmacophoric (S)- or (R)-2-(Alkoxyphosphono)-1-amino-2,2-difluoroethyl Groups
Chen Xie et al.
CHEMISTRY-A EUROPEAN JOURNAL (2016)
Microbial transformations in phosphonate biosynthesis and catabolism, and their importance in nutrient cycling
Jason P. Chin et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2016)
Silver-Mediated C-H Difluoromethylation of Arenes
Jialiang Li et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2016)
Synthesis of difluoromethylenephosphonated oxindoles through visible-vight-induced radical cyclization of N-arylacrylamides
Guojie Yin et al.
JOURNAL OF FLUORINE CHEMISTRY (2016)
Nucleoside Phosphate and Phosphonate Prodrug Clinical Candidates
Peter J. Thornton et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Incorporation of Phosphonate into Benzonaphthyridine Toll-like Receptor 7 Agonists for Adsorption to Aluminum Hydroxide
Alex Cortez et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Nucleophilic Difluoromethylenation of Ketones Using Diethyl (Difluoro(trimethylsilyl)methyl)phosphonate Mediated by 18-Crown-6 Ether/KOAc
Yu-Hui Wang et al.
JOURNAL OF ORGANIC CHEMISTRY (2016)
Photoredox Catalysis in Organic Chemistry
Megan H. Shaw et al.
JOURNAL OF ORGANIC CHEMISTRY (2016)
Synthesis and Antiviral Activity Evaluation of 2′,5′,5′-Trifluoro-Apiosyl Nucleoside Phosphonic Acid Analogs
Eunae Kim et al.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2016)
Geminal difunctionalization of alpha-diazo arylmethylphosphonates: synthesis of fluorinated phosphonates
Yujing Zhou et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2016)
Nucleophilic Tetrafluoroethylation Employing in Situ Formed Organomagnesium Reagents
Alena Budinska et al.
ORGANIC LETTERS (2016)
Resolution of fluorinated aminophosphonic acid enantiomers by precolumn derivatization with following reverse phase liquid chromatography
Michael Yu. Belik et al.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS (2016)
Methods of synthesis and synthetic application of α-diazomethylphosphonates
N. V. Yashin et al.
RUSSIAN CHEMICAL BULLETIN (2016)
Introduction of Functionalized Difluoromethylated Building Blocks Mediated or Catalyzed by Copper
Xavier Pannecoucke et al.
SYNLETT (2016)
Synthesis routes to anti-HIV drugs
Devender Mandala et al.
TETRAHEDRON (2016)
Organic Synthesis Enabled by Light-Irradiation of EDA Complexes: Theoretical Background and Synthetic Applications
Carolina G. S. Lima et al.
ACS CATALYSIS (2016)
Palladium-catalyzed radical cascade difluoroalkylation/cyclization of acrylamide with ethyl difluorobromoacetate
Xiao-Feng Xia et al.
RSC ADVANCES (2016)
Palladium-catalyzed phosphonyldifluoromethylation of alkenes with bromodifluoromethylphosphonate
Zhang Feng et al.
ORGANIC CHEMISTRY FRONTIERS (2016)
Progress in the Development of Pyrophosphate Bioisosteres: Synthesis and Biomedical Potential of 1-Fluoro- and 1,1-Difluoromethylene-1,1-bisphosphonates
Vadim Romanenko et al.
CURRENT ORGANIC CHEMISTRY (2016)
Copper-Mediated Formation of Aryl, Heteroaryl, Vinyl and Alkynyl Difluoromethylphosphonates: A General Approach to Fluorinated Phosphate Mimics
Maria V. Ivanova et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Azide-alkyne cycloaddition-mediated cyclization of phosphonopeptides and their evaluation as PTP1B binders and enrichment tools
Christoph Meyer et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin
Benjamin P. Martin et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
Rat hormone sensitive lipase inhibition by cyclipostins and their analogs
Elena Vasilieva et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
Highly Selective Addition of a Broad Spectrum of Trimethylsilane Pro-nucleophiles to N-tert-Butanesulfinyl Imines
Manas Das et al.
CHEMISTRY-A EUROPEAN JOURNAL (2015)
Copper-Mediated Synthesis of Aryldifluoromethylphosphonates: A Sandmeyer Approach
Alexandre Bayle et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2015)
Preparation of 6-Difluoromethylphosphonated Phenanthridines by Visible-Light-Driven Radical Cyclization of 2-Isocyanobiphenyls
Shuang Wang et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2015)
First synthesis of diethyl N-acetyl-glycosamine-1-difluoromethylphosphonate from 2-nitroglycals as phosphate analog
Thierry Delaunay et al.
JOURNAL OF FLUORINE CHEMISTRY (2015)
Visible-light-mediated radical difluoromethylenephosphonation of 2-isocyanobiaryls with bromodifluoromethylphosphonate for the synthesis of 6-difluoromethylenephosphonyl-phenanthridines
Mei Zhu et al.
JOURNAL OF FLUORINE CHEMISTRY (2015)
Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity
Pijus K. Mandal et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Radical Reactions of Alkyl 2-Bromo-2,2-difluoroacetates with Vinyl Ethers: Omitted Examples and Application for the Synthesis of 3,3-Difluoro-GABA
Ivan S. Kondratov et al.
JOURNAL OF ORGANIC CHEMISTRY (2015)
Combining a Clostridial Enzyme Exhibiting Unusual Active Site Plasticity with a Remarkably Facile Sigmatropic Rearrangement: Rapid, Stereocontrolled Entry into Densely Functionalized Fluorinated Phosphonates for Chemical Biology
Kaushik Panigrahi et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)
Phosphonate derivatives of tetraazamacrocycles as new inhibitors of protein tyrosine phosphatases
Oleksandr L. Kobzar et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2015)
Stereoselective synthesis of fluorinated aminoglycosyl phosphonates
Sanne Bouwman et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2015)
Palladium-Catalyzed Difluoroalkylation of Isocyanides: Access to Difluoroalkylated Phenanthridine Derivatives
Ji-Wei Gu et al.
ORGANIC LETTERS (2015)
Transition-Metal-Free Dehydrosilylative Difluoroamidation of Tetrahydroisoquinolines under Mild Conditions
Qiao Chen et al.
ORGANIC LETTERS (2015)
Copper-Catalyzed Cyclopropanol Ring Opening Csp3-Csp3 Cross-Couplings with (Fluoro)Alkyl Halides
Zhishi Ye et al.
ORGANIC LETTERS (2015)
Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes
Kou-San Ju et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Recent Advances on Palladium Radical Involved Reactions
Qing Liu et al.
ACS CATALYSIS (2015)
Development of Accessible Peptidic Tool Compounds To Study the Phosphatase PTP1B in Intact Cells
Christoph Meyer et al.
ACS CHEMICAL BIOLOGY (2014)
Discovery of Cell-Permeable Inhibitors That Target the BRCT Domain of BRCA1 Protein by Using a Small-Molecule Microarray
Zhenkun Na et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
Thiyl Radicals: From Simple Radical Additions to Asymmetric Catalysis
Hariharaputhiran Subramanian et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
Palladium-Catalyzed Difluoroalkylation of Aryl Boronic Acids: A New Method for the Synthesis of Aryldifluoromethylated Phosphonates and Carboxylic Acid Derivatives
Zhang Feng et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
Transition State in DNA Polymerase β Catalysis: Rate-Limiting Chemistry Altered by Base-Pair Configuration
Keriann Oertell et al.
BIOCHEMISTRY (2014)
Development of caged non-hydrolyzable phosphoamino acids and application to photo-control of binding affinity of phosphopeptide mimetic to phosphopeptide-recognizing protein
Koji Ebisuno et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2014)
Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1
Lucie Aliouane et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2014)
Direct C-H difluoromethylenephosphonation of arenes and heteroarenes with bromodifluoromethyl phosphonate via visible-light photocatalysis
Lin Wang et al.
CHEMICAL COMMUNICATIONS (2014)
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001-2011)
Jiang Wang et al.
CHEMICAL REVIEWS (2014)
Thiyl Radicals in Organic Synthesis
Fabrice Denes et al.
CHEMICAL REVIEWS (2014)
Selectfluor and NFSI exo-Glycal Fluorination Strategies Applied to the Enhancement of the Binding Affinity of Galactofuranosyltransferase GlfT2 Inhibitors
Lidia Dumitrescu et al.
CHEMISTRY-A EUROPEAN JOURNAL (2014)
Trifluoromethyl Ethers and -Thioethers as Tools for Medicinal Chemistry and Drug Discovery
Gregory Landelle et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2014)
Tamiphosphor monoesters as effective anti-influenza agents
Chun-Lin Chen et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
Synthesis and spectral properties of α,α-difluorinated β-iminophosphonates
Magdalena Rapp et al.
JOURNAL OF FLUORINE CHEMISTRY (2014)
McKenna Reaction-Which Oxygen Attacks Bromotrimethylsilane?
Katarzyna M. Blazewska
JOURNAL OF ORGANIC CHEMISTRY (2014)
Cell-Permeable Bicyclic Peptide Inhibitors against Intracellular Proteins
Wenlong Lian et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Fluorophosphonylated Monomers for Dental Applications
Mathieu Derbanne et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2014)
Probing SH2-domains using Inhibitor Affinity Purification (IAP)
Michael Hoefener et al.
PROTEOME SCIENCE (2014)
Copper-catalyzed cross-coupling of bromozinc-difluoromethylphosphonate with iodo/bromo-aryl triazenes
Zhang Feng et al.
ORGANIC CHEMISTRY FRONTIERS (2014)
Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
Keith Clinch et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Phosphonate Analogues of Arabinose 5-Phosphate: Putative Ligands for Arabinose 5-Phosphate Isomerases
Luca Gabrielli et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2013)
Mono and difluorination of centers α to sulfonates and phosphonates using AcOF
Inna Vints et al.
JOURNAL OF FLUORINE CHEMISTRY (2013)
Cuprous chloride promoted coupling reaction of diethoxyphosphinyldifluoromethylcadmium reagent with aryl iodides: A practical and convenient preparation of α,α-difluoro benzylic phosphonates
Weiming Qiu et al.
JOURNAL OF FLUORINE CHEMISTRY (2013)
Nucleophilic fluoroalkylation of (bromomethyl)pinacolborane using silicon reagents
Vitalij V. Levin et al.
JOURNAL OF FLUORINE CHEMISTRY (2013)
Synthesis and Evaluation of L-Rhamnose 1C-Phosphonates as Nucleotidylyltransferase Inhibitors
Matthew W. Loranger et al.
JOURNAL OF ORGANIC CHEMISTRY (2013)
Synthesis of (α,α-Difluoropropargyl)phosphonates via Aldehyde-to-Alkyne Homologation
Romana Pajkert et al.
JOURNAL OF ORGANIC CHEMISTRY (2013)
Organophosphonates revealed: new insights into the microbial metabolism of ancient molecules
John W. McGrath et al.
NATURE REVIEWS MICROBIOLOGY (2013)
Medicinal Chemistry of Fluorinated Cyclic and Acyclic Nucleoside Phosphonates
Ondrej Baszczynski et al.
MEDICINAL RESEARCH REVIEWS (2013)
Copper-mediated oxidative difluoromethylenation of aryl boronic acids with alpha-silyldifluoromethylphosphonates: a new method for aryldifluorophosphonates
Xueliang Jiang et al.
NEW JOURNAL OF CHEMISTRY (2013)
Conformational Motions Regulate Phosphoryl Transfer in Related Protein Tyrosine Phosphatases
Sean K. Whittier et al.
SCIENCE (2013)
Radical conjugate addition of ambiphilic fluorinated free radicals
Coralie De Schutter et al.
TETRAHEDRON (2013)
Recent advances in the synthesis of fluorinated aminophosphonates and aminophosphonic acids
Kostiantyn V. Turcheniuk et al.
RSC ADVANCES (2013)
Discovery of potent, selective and orally bioavailable triaryl-sulfonamide based PTP1B inhibitors
Dipam Patel et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Efficient asymmetric synthesis of trifluoromethylated β-aminophosphonates and their incorporation into dipeptides
Kostiantyn V. Turcheniuk et al.
CHEMICAL COMMUNICATIONS (2012)
Synthesis of a Phosphoserine Mimetic Prodrug with Potent 14-3-3 Protein Inhibitory Activity
Allison Arrendale et al.
CHEMISTRY & BIOLOGY (2012)
Synthesis and evaluation of new phosphonic, bisphosphonic and difluoromethylphosphonic acid monomers for dental application
Yohann Catel et al.
EUROPEAN POLYMER JOURNAL (2012)
Rational Design of Selective Organoruthenium Inhibitors of Protein Tyrosine Phosphatase 1B
Jun Xiang Ong et al.
INORGANIC CHEMISTRY (2012)
Synthesis of N-substituted α,α-difluoro-β-aminophosphonates by addition of diethyl lithiodifluoromethylphosphonate to imines
Prabhakar Cherkupally et al.
JOURNAL OF FLUORINE CHEMISTRY (2012)
Nucleophilic additions of [(diethoxyphosphoryl)difluoromethyl]lithium to α,β-unsaturated compounds
Prabhakar Cherkupally et al.
JOURNAL OF FLUORINE CHEMISTRY (2012)
Fluorophosphonylated Nucleoside Derivatives as New Series of Thymidine Phosphorylase Multisubstrate Inhibitors
Sonia Amel Diab et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Reactions of Sulfur- and Phosphorus-Substituted Fluoroalkylating Silicon Reagents with Imines and Enamines under Acidic Conditions
Mikhail D. Kosobokov et al.
JOURNAL OF ORGANIC CHEMISTRY (2012)
Copper-Mediated Oxidative Cross-Coupling Reaction of Terminal Alkynes with α-Silyldifluoromethylphosphonates: An Efficient Method for α,α-Difluoropropargylphosphonates
Xueliang Jiang et al.
ORGANIC LETTERS (2012)
Copper Catalyzed Cross-Coupling of Iodobenzoates with Bromozinc-difluorophosphonate
Zhang Feng et al.
ORGANIC LETTERS (2012)
Influence of the difluoromethylene group (CF2) on the conformation and properties of selected organic compounds
David O'Hagan et al.
PURE AND APPLIED CHEMISTRY (2012)
Synthesis of Methylphosphonic Acid by Marine Microbes: A Source for Methane in the Aerobic Ocean
William W. Metcalf et al.
SCIENCE (2012)
Taming of Fluoroform: Direct Nucleophilic Trifluoromethylation of Si, B, S, and C Centers
G. K. Surya Prakash et al.
SCIENCE (2012)
Copper-Catalyzed Aerobic Oxidative Trifluoromethylation of H-Phosphonates Using Trimethyl(trifluoromethyl)silane
Lingling Chu et al.
SYNTHESIS-STUTTGART (2012)
Synthesis and enzymatic evaluation of ketose phosphonates: the interplay between mutarotation, monofluorination and acidity
Stephanie M. Forget et al.
CHEMICAL SCIENCE (2012)
The use of phosphate bioisosteres in medicinal chemistry and chemical biology
Thomas S. Elliott et al.
MEDCHEMCOMM (2012)
Visible light photoredox catalysis: applications in organic synthesis
Jagan M. R. Narayanam et al.
CHEMICAL SOCIETY REVIEWS (2011)
Discovery of Orally Active, Potent, and Selective Benzotriazole-Based PTP1B Inhibitors
Dipam Patel et al.
CHEMMEDCHEM (2011)
Synthesis of Fluoroalkylated Allylic-β-hydroxyesters and Fluoroalkylated β,Y-Epoxy Esters from Ethyl 3-Hydroxy-4-pentenoate
Fang Xiang et al.
CHINESE JOURNAL OF CHEMISTRY (2011)
Application of Silicon-based Methodologies for the Synthesis of Functionalized Mono- and Bisphosphonic Acids
Vadim D. Romanenko et al.
CURRENT ORGANIC CHEMISTRY (2011)
Nucleophilic Trifluoromethylation of C=N Bonds
Alexander D. Dilman et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2011)
Synthetic and mechanistic aspects of halo-F-methylphosphonates
Richard M. Flynn et al.
JOURNAL OF FLUORINE CHEMISTRY (2011)
A facile method to construct cyclic α,α-difluoromethylenephosphonate-A novel cyclic phosphate mimic
Yun Lin et al.
JOURNAL OF FLUORINE CHEMISTRY (2011)
Potent and Selective Phosphopeptide Mimetic Prodrugs Targeted to the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3
Pijus K. Mandal et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Selective Synthesis of α-Fluoro-β-keto- and α-Fluoro-β-aminophosphonates via Electrophilic Fluorination by Selectfluor
Kinga Radwan-Olszewska et al.
JOURNAL OF ORGANIC CHEMISTRY (2011)
Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis
David A. Nagib et al.
NATURE (2011)
Synthesis of difluoromethylphosphonamidates by direct addition of amine
Lucie Aliouane et al.
TETRAHEDRON LETTERS (2011)
Overexpressed proteins may act as mops removing their ligands from the host cells: A case study of calf PNP
Katarzyna Breer et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs
Sadao Hikishima et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase
Arindam Talukdar et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Antiproliferative Activity of Purine Nucleoside Phosphorylase Multisubstrate Analogue Inhibitors Containing Difluoromethylene Phosphonic Acid against Leukaemia and Lymphoma Cells
Ljubica Glavas-Obrovac et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2010)
Synthesis and Applications of tert-Butanesulfinamide
MaryAnn T. Robak et al.
CHEMICAL REVIEWS (2010)
9-Deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid are slow-binding picomolar inhibitors of trimeric purine nucleoside phosphorylase
Katarzyna Breer et al.
FEBS JOURNAL (2010)
Synthesis of novel α-CF3-trifluoroalanine derivatives containing N-(diethoxyphosphoryl)difluoroacetyl group
Romana Pajkert et al.
JOURNAL OF FLUORINE CHEMISTRY (2010)
Asymmetric synthesis of fluorine-containing amines, amino alcohols, α- and β-amino acids mediated by chiral sulfinyl group
Alexander E. Sorochinsky et al.
JOURNAL OF FLUORINE CHEMISTRY (2010)
Halogenated β,γ-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase β: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues
Vinod K. Batra et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Solid-Phase Synthetic Route to Multiple Derivatives of a Fundamental Peptide Unit
William L. Scott et al.
MOLECULES (2010)
Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB
Katherine A. Rawls et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2010)
Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid
G. K. Surya Prakash et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Difluoromethylenephosphonates: synthesis and transformations
K. S. Chunikhin et al.
RUSSIAN CHEMICAL REVIEWS (2010)
A divergent approach to highly substituted benzothiepinones and to 2,3-dihydrothieno[2,3-b]thiopyran-4-ones
Peter Boutillier et al.
TETRAHEDRON-ASYMMETRY (2010)
Biosynthesis of Phosphonic and Phosphinic Acid Natural Products
William W. Metcalf et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2009)
Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA
Katherine A. Rawls et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Synthesis, SAR, and X-ray structure of tricyclic compounds as potent FBPase inhibitors
Tomoharu Tsukada et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
tert-Butanesulfinimines: structure, synthesis and synthetic applications
Franck Ferreira et al.
CHEMICAL SOCIETY REVIEWS (2009)
The α,α-Difluorinated Phosphonate L-pSer-Analogue: An Accessible Chemical Tool for Studying Kinase-Dependent Signal Transduction
Kaushik Panigrahi et al.
CHEMISTRY & BIOLOGY (2009)
Syntheses of 5-Chlorouracils/Thymines with 1-[Phosphono(Methyl/Difluoromethyl)]-1,2-Unsaturated-Moiety-Substituted Methyl Groups at N(1) and Human Thymidine Phosphorylase Inhibitory Activity
Matthew R. Birck et al.
HELVETICA CHIMICA ACTA (2009)
The amination of difluoro(diethoxyphosphoryl)acetyl chloride: Facile synthetic route to novel amides containing difluoromethylenephosphonate moiety
Romana Pajkert et al.
JOURNAL OF FLUORINE CHEMISTRY (2009)
Nucleophilic difluoromethylenation of aldehydes and ketones using diethyl difluoro(trimethylsilyl)methylphosphonate
Anastasia V. Alexandrova et al.
JOURNAL OF FLUORINE CHEMISTRY (2009)
Diastereoselective Synthesis of γ-Amino-δ-hydroxy-α,α-difluorophosphonates: A Vehicle for Structure-activity Relationship Studies on SMA-7, a Potent Sphingomyelinase Inhibitor
Takehiro Yamagishi et al.
JOURNAL OF ORGANIC CHEMISTRY (2009)
Enantioselective α-Trifluoromethylation of Aldehydes via Photoredox Organocatalysis
David A. Nagib et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Synthesis of fluorophosphonylated acyclic nucleotide analogues via copper(I)-catalyzed Huisgen 1-3 dipolar cycloaddition
Sonia Amel Diab et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2009)
α,β-Difluoromethylene Deoxynucleoside 5′-Triphosphates: A Convenient Synthesis of Useful Probes for DNA Polymerase β Structure and Function
Thomas G. Upton et al.
ORGANIC LETTERS (2009)
Solid-Phase Synthesis of Amino- and Carboxyl-Functionalized Unnatural α-Amino Acid Amides
William L. Scott et al.
ORGANIC LETTERS (2009)
Synthesis of Phosphatase-Stable, Cell-Permeable Peptidomimetic Prodrugs That Target the SH2 Domain of Stat3
Pijus K. Mandal et al.
ORGANIC LETTERS (2009)
An Efficient and Highly Selective Synthesis of (Z)-Fluoroenol Phosphates from Hydroxy Difluorophosphonates
Petr Beier et al.
SYNTHESIS-STUTTGART (2009)
Preparation of orthogonally protected (2S,3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) as a phosphatase-stable phosphothreonine mimetic and its use in the synthesis of polo-box domain-binding peptides
Fa Liu et al.
TETRAHEDRON (2009)
IspH Protein of the Deoxyxylulose Phosphate Pathway: Mechanistic Studies with C-1-Deuterium-Labeled Substrate and Fluorinated Analogue
Youli Xiao et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
A re-examination of the difluoromethylenesulfonic acid group as a phosphotyrosine mimic for PTP1B inhibition
Munawar Hussain et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)-methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor
Yongxin Han et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
PTP1B inhibitors: Synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold
Christopher P. Holmes et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Understanding organofluorine chemistry. An introduction to the C-F bond
David O'Hagan
CHEMICAL SOCIETY REVIEWS (2008)
Novel Acyl Phosphate Mimics that Target PlsY, an Essential Acyltransferase in Gram-Positive Bacteria
Kimberly D. Grimes et al.
CHEMMEDCHEM (2008)
Synthetic and mechanistic aspects of the reactions between bromodifluoromethyltriphenylphosphonium bromide and dibromofluoromethyltriphenylphosphonium bromide and trialkylphosphites
Richard M. Flynn et al.
JOURNAL OF FLUORINE CHEMISTRY (2008)
Prodrugs of phosphates and phosphonates
Scott J. Hecker et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Bismethylene triphosphate nucleotides of uridine 4-phosphate analogues: A new class of anionic pyrimidine nucleotide analogues
Scott D. Taylor et al.
JOURNAL OF ORGANIC CHEMISTRY (2008)
Efficient synthesis of fluorophosphonylated alkyles by ring-opening reaction of cyclic sulfates
Sonia Amel Diab et al.
ORGANIC LETTERS (2008)
Nucleophilic difluoromethylation and difluoromethylenation of aldehydes and ketones using diethyl difluoromethylphosphonate
Petr Beier et al.
TETRAHEDRON (2008)
TiCl4 and Grignard reagent-promoted ring-opening reactions of various epoxides:: synthesis of γ-hydroxy-α,α-difluoromethylenephosphonates
Romana Pajkert et al.
TETRAHEDRON LETTERS (2008)
Photochemical generation of difluoromethyl radicals having various functional groups and their highly regioselective addition to olefins and aromatic substitution
Hirokatsu Nagura et al.
TETRAHEDRON (2007)
Simple synthesis of some unsaturated 1,1-difluoro-2-hydroxyethylphosphonates
Romana Pajkert et al.
JOURNAL OF FLUORINE CHEMISTRY (2007)
Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB
Matthew B. Soellner et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP
Sadao Hikishima et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Synthesis of γ-butyrolactones containing α,α-difluoromethylenyl bisphosphonate initiated by Na2S2O4
Xueyan Yang et al.
JOURNAL OF FLUORINE CHEMISTRY (2007)
Synthesis and cell-based activity of a potent and selective protein tyrosine phosphatase 1B inhibitor prodrug
Irene G. Boutselis et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Convenient synthesis of beta-allenic alpha-difluoromethylenephosphonic acid monoesters: Potential synthons for cyclic phosphate mimics
Yun Lin et al.
CHINESE CHEMICAL LETTERS (2007)
Synthesis of methylene- and difluoromethylenephosphonate analogues of uridine-4-phosphate and 3-deazauridine-4-phosphate
Scott D. Taylor et al.
JOURNAL OF ORGANIC CHEMISTRY (2006)
Diastereoselective addition of diethyl difluoromethylphosphonate to enantiopure sulfinimines:: synthesis of α,α-difluoro-β-aminophosphonates, phosphonic acids, and phosphonamidic acids
Gerd-Volker Roeschenthaler et al.
TETRAHEDRON (2006)
DFTMP, an NMR reagent for assessing the near-neutral pH of biological samples
Michael D. Reily et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Fluorinated phosphonates: Synthesis and biomedical application
Vadim D. Romanenko et al.
CHEMICAL REVIEWS (2006)
Synthesis of 3-trifluoro-2-hydroxy/amino-1-fluoropropylphosphonates
Zheng Wei-Hong et al.
CHINESE JOURNAL OF CHEMISTRY (2006)
First iodocyclization of β-allenic phosphonates:: a novel synthesis of α-difluoromethylenephostones
Yun Lin et al.
TETRAHEDRON LETTERS (2006)
Experimental and theoretical studies on the transannular cyclizations of 3,7-dimethylenebicyclo[3.3.1]nonane with polyfluoroalkyl radicals
Maxim V. Ponomarenko et al.
JOURNAL OF FLUORINE CHEMISTRY (2006)
Synthesis and evaluation of ketophosph(on)ates as, β-lactamase inhibitors
Senthil K. Perumal et al.
JOURNAL OF ORGANIC CHEMISTRY (2006)
Electrolytic partial fluorination of organic compounds 84 Anodic mono- and difluorination of benzylphosphonate derivatives
Bakenova Zagipa et al.
JOURNAL OF FLUORINE CHEMISTRY (2006)
Synthesis and biological evaluation of 9-(5′,5′-difluoro-5′-phosphonopentyl)guanine derivatives for PNP-inhibitors
S Hikishima et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Remote asymmetric trifluoromethylation induced by chiral sulfinyl group: synthesis of enantiomerically pure 1-(2-naphthyl)-2,2,2-trifluoroethanol
H Sugimoto et al.
TETRAHEDRON LETTERS (2006)
Phosphonodifluoromethyl and phosphonothiodifluoromethyl radicals. Generation and addition onto alkenes and alkynes
S Pignard et al.
JOURNAL OF ORGANIC CHEMISTRY (2006)
Lewis acid-catalyzed tri- and difluoromethylation reactions of aldehydes
Satoshi Mizuta et al.
CHEMICAL COMMUNICATIONS (2006)
Design and synthesis of phosphonodifluoromethyl phenylalanine (F(2)Pmp): A useful phosphotyrosyl mimetic
Terrence R. Burke
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2006)
Electrochemical partial fluorination of organic compounds.: 80.: Synthesis of cyclic α-arylthio-α-monofluorophosphonate esters
Y Cao et al.
JOURNAL OF ORGANIC CHEMISTRY (2005)
Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics
AP Combs et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARγ, and inhibitors of autotaxin
GG Durgam et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
α-fluorinated ethers, thioethers, and amines:: Anomerically biased species
F Leroux et al.
CHEMICAL REVIEWS (2005)
Asymmetric synthesis of α,α-difluoro-β-amino phosphonic acids using sulfinimines
GV Röschenthaler et al.
TETRAHEDRON LETTERS (2004)
Synthesis and some heterocyclization reactions of new diethyl (1,1-difluoro-3,3-dicyano-2-trifluoromethylallyl)phosphonate and ethyl 3,3-dicyano-2-[(diethoxyphosphoryl)difluoromethyl]acrylate
PV Pasternak et al.
JOURNAL OF FLUORINE CHEMISTRY (2004)
Syntheses of ω-hydroxy-α,α-difluoromethylphosphonates by oxacycle ring-opening reactions
P Ozouf et al.
ORGANIC LETTERS (2004)
A difluorosulfide as a Freon-free source of phosphonodifluoromethyl carbanion
A Henry-dit-Quesnel et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2003)
Acyclic analogues of adenosine bisphosphates as P2Y receptor antagonists: Phosphate substitution leads to multiple pathways of inhibition of platelet aggregation
B Xu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Protein tyrosine phosphatase 1B inhibitors for diabetes
TO Johnson et al.
NATURE REVIEWS DRUG DISCOVERY (2002)
Synthesis of thiazolines linked to a difluoromethylphosphonate diester via dithioester chemistry
E Pfund et al.
ORGANIC LETTERS (2002)
The crystal structure of phosphinothricin in the active site of glutamine synthetase illuminates the mechanism of enzymatic inhibition
HS Gill et al.
BIOCHEMISTRY (2001)
Sulfanyl- and selanyldifluoromethylphosphonates as a source of phosphonodifluoromethyl radicals and their addition onto alkenes
T Lequeux et al.
ORGANIC LETTERS (2001)
Synthesis of aryldifluoromethylphosphonothioic acids from O,O-diethyl aryldifluoromethylphosphonothioates
T Yokomatsu et al.
JOURNAL OF ORGANIC CHEMISTRY (2000)
Facile syntheses of building blocks for the construction of phosphotyrosine mimetics
GS Cockerill et al.
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 (2000)
Share Paper
