Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 363, Issue 10, Pages 2594-2609Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202100143
Keywords
2-Aroylbenzofurans; Double Cyclocondensation; o-Hydroxyacetophenones; alpha-Hydroxy Arylketones; (4+1) Annulation
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Funding
- Ministry of Science and Technology of the Republic of China (Taiwan) [MOST 109-2113-M-037-014-MY3]
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This paper presents a high-yield and facile method for the synthesis of sulfonyl 2-aroylbenzofurans under mild conditions with water as the only byproduct. Various metal triflate-promoted reactions were investigated for efficient annulation reaction.
In this paper, a high-yield, facile route for the scalable synthesis of sulfonyl 2-aroylbenzofurans via a Bi(OTf)(3)-mediated intermolecular double cyclocondensation of alpha-sulfonyl o-hydroxyacetophenones with substituted alpha-hydroxy arylketones under mild open-vessel reaction conditions is described. In the overall reaction, water is generated as the only byproduct. Various metal triflate-promoted reactions and conditions are investigated for the efficient one-pot (4 + 1) annulation reaction.
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