Synthesis of Perinaphthenones via BF3.Et2O Mediated One-Pot Cascade 4,5-Annulation Reactions of 1-Naphthols and Ynones

C-4-C-5 periannulation of 1-naphthols and ynones via (BF3Et2O)-Et-. mediated one-pot cascade under metal and solvent-free conditions have been developed for the synthesis of perinaphthenones. Furthermore, this strategy features the formation of new periannulation at C-4-C-5 positions of alpha-naphthol, synthesis of highly substituted perinaphthenones, broad substrate scope, readily available starting materials and good to moderate yields. The perinaphthenones products synthesized here have exhibited interesting photo physical properties

Automated summary

A new method has been developed for the metal and solvent-free one-pot cascade synthesis of perinaphthenones from 1-naphthols and ynones mediated by (BF3Et2O)-Et-. This strategy allows for the formation of new periannulation at C-4-C-5 positions of alpha-naphthol, resulting in highly substituted perinaphthenones with good to moderate yields. The synthesized perinaphthenones products exhibit interesting photo physical properties.