Tailoring Materials for Modulation of Macrophage Fate

Human immune system acts as a pivotal role in the tissue homeostasis and disease progression. Immunomodulatory biomaterials that can manipulate innate immunity and adaptive immunity hold great promise for a broad range of prophylactic and therapeutic purposes. This review is focused on the design strategies and principles of immunomodulatory biomaterials from the standpoint of materials science to regulate macrophage fate, such as activation, polarization, adhesion, migration, proliferation, and secretion. It offers a comprehensive survey and discussion on the tunability of material designs regarding physical, chemical, biological, and dynamic cues for modulating macrophage immune response. The range of such tailorable cues encompasses surface properties, surface topography, materials mechanics, materials composition, and materials dynamics. The representative immunoengineering applications selected herein demonstrate how macrophage-immunomodulating biomaterials are being exploited for cancer immunotherapy, infection immunotherapy, tissue regeneration, inflammation resolution, and vaccination. A perspective on the future research directions of immunoregulatory biomaterials is also provided.

Automated summary

This review focuses on the design strategies and principles of immunomodulatory biomaterials to regulate macrophage fate, as well as their potential applications in various immunengineering fields. The tunability of material designs, including physical, chemical, biological, and dynamic cues, plays a crucial role in modulating macrophage immune response. The selected immunoengineering applications demonstrate how macrophage-immunomodulating biomaterials are being utilized for cancer immunotherapy, infection immunotherapy, tissue regeneration, inflammation resolution, and vaccination.