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Vascular permeability in cancer and infection as related to macromolecular drug delivery, with emphasis on the EPR effect for tumor-selective drug targeting
Hiroshi Maeda
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TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma
Jieqiong Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Bradykinin-potentiating peptides: Beyond captopril
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TOXICON (2012)
Targeting platelet function to improve drug delivery
Melanie Demers et al.
ONCOIMMUNOLOGY (2012)
Increased Efficacy of Breast Cancer Chemotherapy in Thrombocytopenic Mice
Melanie Demers et al.
CANCER RESEARCH (2011)
Hedgehog signaling and therapeutics in pancreatic cancer
Fergal C. Kelleher
CARCINOGENESIS (2011)
A phase I/II trial of non-pegylated liposomal doxorubicin, docetaxel and trastuzumab as first-line treatment in HER-2-positive locally advanced or metastatic breast cancer
D. Amadori et al.
EUROPEAN JOURNAL OF CANCER (2011)
RIBBON-2: A Randomized, Double-Blind, Placebo-Controlled, Phase III Trial Evaluating the Efficacy and Safety of Bevacizumab in Combination With Chemotherapy for Second-Line Treatment of Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer
Adam M. Brufsky et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
How platelets safeguard vascular integrity
B. Ho-Tin-Noe et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2011)
Molecular mechanisms and clinical applications of angiogenesis
Peter Carmeliet et al.
NATURE (2011)
Pirfenidone
Luca Richeldi et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells
Debanjan Chakroborty et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Cyclopamine and Hedgehog Signaling: Chemistry, Biology, Medical Perspectives
Philipp Heretsch et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
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Mark J. McKeage et al.
CANCER (2010)
Conjugation of bevacizumab to cationic liposomes enhances their tumor-targeting potential
Geoffrey M. Kuesters et al.
NANOMEDICINE (2010)
Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment
Vivian Barry-Hamilton et al.
NATURE MEDICINE (2010)
Delivering nanomedicine to solid tumors
Rakesh K. Jain et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2010)
Pegylated liposomal doxorubicin and trastuzumab as 1st and 2nd line therapy in her2/neu positive metastatic breast cancer: a multicenter phase II trial
Elmar Stickeler et al.
BREAST CANCER RESEARCH AND TREATMENT (2009)
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Kandice R. Levental et al.
CELL (2009)
4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3
Anne Kultti et al.
EXPERIMENTAL CELL RESEARCH (2009)
Phase II Trial of Combination Therapy With Bortezomib, Pegylated Liposomal Doxorubicin, and Dexamethasone in Patients With Newly Diagnosed Myeloma
Andrzej J. Jakubowiak et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging
Benjamin J. Vakoc et al.
NATURE MEDICINE (2009)
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
Hua Tian et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive et al.
SCIENCE (2009)
Regulation of endothelial junctional permeability
Emily Vandenbroucke et al.
CONTROL AND REGULATION OF TRANSPORT PHENOMENA IN THE CARDIAC SYSTEM (2008)
Tumor necrosis factor α mediates homogeneous distribution of liposomes in murine melanoma that contributes to a better tumor response
Ann L. B. Seynhaeve et al.
CANCER RESEARCH (2007)
The tumour microenvironment as a target for chemoprevention
Adriana Albini et al.
NATURE REVIEWS CANCER (2007)
Sorafenib in advanced clear-cell renal-cell carcinoma
Bernard Escudier et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
Phase I and pharmacokinetic study of docetaxel, irinotecan, and celecoxib in patients with advanced non-small cell lung cancer
A Argiris et al.
INVESTIGATIONAL NEW DRUGS (2006)
Tumor vascular permeabilization by vascular-targeting photosensitization: Effects, mechanism, and therapeutic implications
B Chen et al.
CLINICAL CANCER RESEARCH (2006)
Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage
J Kisucka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
RK Jain
SCIENCE (2005)
Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX™/Doxil®) versus conventional doxorubicin for first-line treatment of metastatic breast cancer
MER O'Brien et al.
ANNALS OF ONCOLOGY (2004)
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
CG Willett et al.
NATURE MEDICINE (2004)
High interstitial fluid pressure -: An obstacle in cancer therapy
CH Heldin et al.
NATURE REVIEWS CANCER (2004)
Primary treatment of multiple myeloma with thalidomide, vincristine, liposomal doxorubicin and dexamethasone (T-VAD doxil): a phase II multicenter study
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ANNALS OF ONCOLOGY (2004)
Radiation-guided drug delivery to tumor blood vessels results in improved tumor growth delay
L Geng et al.
JOURNAL OF CONTROLLED RELEASE (2004)
Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinases
J Wu et al.
JAPANESE JOURNAL OF CANCER RESEARCH (2001)