Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 174, Issue -, Pages 53-86Publisher
ELSEVIER
DOI: 10.1016/j.addr.2021.01.019
Keywords
Liposomes; Drug; Topical routes; Local delivery; Administration; Ocular; Pulmonary; Nasal; Oral; Intratumoral; Vaginal; Vaccine; COVID-19
Categories
Funding
- project ''Development of Innovative Neuroprotective Neurogenerative Synthetic MicroNeurotrophins'' [MIS-5032840]
- Operational Programme Competitiveness, Entrepreneurship and Innovation (NSRF 2014-2020)
- European Union (European Regional Development Fund)
- project: Preclinical development of INNOvative FORmulations of antibiotics for intraocular administration for the treatment/prevention of postoperative endophthalmIitis [MIS-5031792]
- project: Development of Innovative Nanocarriers of Insulinlike Peptides with prolonged action - Management Authority of Western Greece Region
- Public Investment Programme of Greece
- European Regional Development Fund of the European Union
- Greek national funds through the Operational Program Competitiveness, Enterpreneurship and Innovation, under the call RESEARCH-CREATE-INNOVATE [T1EDK-03186, T1EDK00422]
- Greek national funds through the Operational Program Western Greece 2004-2020, Enhancing the Competitiveness and Extroversion of Businesses, under the call MiCROELECTRONICS & ADVANCED MATERIALS [DE1MP-0028521]
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Localized or topical drug administration, in combination with nanoparticulate formulations like liposomes, can offer advantages such as prolonged retention of high drug loads, controlled release, reduced side effects, and increased protection from harsh environments. Targeted liposomal formulations may enhance these therapeutic advantages in drug delivery.
Localized or topical administration of drugs may be considered as a potential approach for overcoming the problems caused by the various biological barriers encountered in drug delivery. The combination of using localized administration routes and delivering drugs in nanoparticulate formulations, such as liposomes, may have additional advantages. Such advantages include prolonged retention of high drug loads at the site of action and controlled release of the drug, ensuring prolonged therapeutic effect; decreased potential for side-effects and toxicity (due to the high topical concentrations of drugs); and increased protection of drugs from possible harsh environments at the site of action. The use of targeted liposomal formulations may further potentiate any acquired therapeutic advantages. In this review we present the most advanced cases of localized delivery of liposomal formulations of drugs, which have been investigated pre-clinically and clinically in the last ten years, together with the reported therapeutic advantages, in each case. (c) 2021 Elsevier B.V. All rights reserved.
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