Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 169, Issue -, Pages 40-50Publisher
ELSEVIER
DOI: 10.1016/j.addr.2020.12.003
Keywords
Antigen presentation; ATG5; Beclin 1; Cytotoxic T lymphocytes; Dendritic cells; CGAS/STING signaling; Mitophagy; TREG cells
Categories
Funding
- Karolinska Institute Starting Grant
- Swedish Research Council [2019_02050_3]
- Jeanssons Stiftelser
- Ramon y Cajal Program [RYC-2018-025099-I]
- Ligue contre le Cancer (equipe labellisee)
- Agence National de la Recherche (ANR) - Projets blancs
- ANR
- Association pour la recherche sur le cancer (ARC)
- Canceropole Ile-de-France
- Fondation pour la Recherche Medicale (FRM)
- European Research Area Network on Cardiovascular Diseases (ERA-CVD, MINOTAUR)
- Gustave Roussy Odyssea
- European Union Horizon 2020 Project Oncobiome
- High-end Foreign Expert Program in China [GDW20171100085, GDW20181100051]
- Institut National du Cancer (INCa)
- Inserm (HTE)
- Institut Universitaire de France
- LeDucq Foundation
- LabEx Immuno-Oncology
- Seerave Foundation
- SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
- Breakthrough Level 2 grant from the US Department of Defense (DoD), Breast Cancer Research Program (BRCP) [BC180476P1]
- 2019 Laura Ziskin Prize in Translational Research from the Stand Up to Cancer (SU2C) [ZP-6177]
- Mantle Cell Lymphoma Research Initiative (MCL-RI) grant from the Leukemia and Lymphoma Society (LLS)
- startup grant from the Dept. of Radiation Oncology at Weill Cornell Medicine (New York, US)
- Rapid Response Grant from the Functional Genomics Initiative (New York, US)
- Lytix (Oslo, Norway)
- Phosplatin (NewYork, US)
- Chancelerie des universites de Paris (Legs Poix)
- Fondation Carrefour
- RHU Torino Lumiere
- ERA-Net for Research on Rare Diseases
- Swedish Research Council [2019-02050] Funding Source: Swedish Research Council
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Autophagy is crucial for cellular homeostasis in eukaryotic cells, benefiting both normal and malignant cells. It plays a key role in the immunological control of malignant transformation, tumor progression, and response to therapy. However, the effects of autophagy activation or inhibition on tumor growth and therapeutic responses are context-dependent, highlighting the complex interplay between autophagy and immuno-oncology in cancer.
Autophagy is quintessential for the maintenance of cellular homeostasis in all eukaryotic cells, explaining why both normal and malignant cells benefit from proficient autophagic responses. Moreover, autophagy is intimately involved in the immunological control of malignant transformation, tumor progression and response to therapy. However, the net effect of autophagy activation or inhibition on the natural growth or therapeutic response of tumors evolving in immunocompetent hosts exhibits a considerable degree of context dependency. Here, we discuss the complex cross-talk between autophagy and immuno-oncology as delineated by genetic and pharmacological approaches in mouse models of cancer. (c) 2020 Elsevier B.V. All rights reserved.
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