4.8 Article

Platinum-Doped Prussian Blue Nanozymes for Multiwavelength Bioimaging Guided Photothermal Therapy of Tumor and Anti-Inflammation

Journal

ACS NANO
Volume 15, Issue 3, Pages 5189-5200

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c10388

Keywords

nanozyme; Prussian blue; Pt nanoparticle; photothermal therapy; inflammation; tumor

Funding

  1. National Natural Science Foundation of China [51690152, 51873161, 51833007]

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This study developed platinum-doped Prussian blue (PtPB) nanozymes with tunable spectral absorption, high photothermal conversion efficiency, and antioxidative catalytic activity, providing a new paradigm for designing safe and efficient photothermal agents for complex tumor diseases. The PtPB nanozymes exhibited tunable LSPR frequency, significantly enhanced photothermal conversion efficiency, and good biosafety after intravenous injection. The experimental and theoretical results revealed the mechanisms behind the enhanced photothermal conversion efficiency of PtPB with tunable LSPR frequency.
Developing appropriate photothermal agents to meet complex clinical demands is an urgent challenge for photothermal therapy of tumors. Here, platinum-doped Prussian blue (PtPB) nanozymes with tunable spectral absorption, high photothermal conversion efficiency, and good antioxidative catalytic activity are developed by one-step reduction. By controlling the doping ratio, PtPB nanozymes exhibit tunable localized surface plasmon resonance (LSPR) frequency with significantly enhanced photothermal conversion efficiency and allow multiwavelength photoacoustic/infrared thermal imaging guided photothermal therapy. Experimental band gap and density functional theory calculations further reveal that the decrement of free carrier concentrations and increase in circuit paths of electron transitions co-contribute to the enhanced photothermal conversion efficiency of PtPB with tunable LSPR frequency. Benefiting from antioxidative catalytic activity, PtPB can simultaneously relieve inflammation caused by hyperthermia. Moreover, PtPB nanozymes exhibited good biosafety after intravenous injection. Our findings provide a paradigm for designing safe and efficient photothermal agents to treat complex tumor diseases.

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