Journal
ACS NANO
Volume 15, Issue 2, Pages 1960-2004Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c06688
Keywords
patient-friendly diagnosis and treatment; point-of-care testing; portable and wearable biosensor; noninvasive biosensor; implantable devices; wireless communication; functional materials; biocompatibility
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Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [1415169760, 2019R1A5A8080326, 2019R1C1C1006928]
- Bio & Medical Technology Development Program [NRF-2017M3A9E4047243]
- KAIST
- National Research Foundation of Korea [2019R1C1C1006928] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Patient-friendly medical diagnostics and treatments have gained significant attention for their rapid development of portable biosensors and implantable devices. Challenges related to wearable biosensors are highlighted, along with advances in implantable devices and patient-friendly surgical approaches.
Patient-friendly medical diagnostics and treatments have been receiving a great deal of interest due to their rapid and cost-effective health care applications with minimized risk of infection, which has the potential to replace conventional hospital-based medical procedures. In particular, the integration of recently developed materials into health care devices allows the rapid development of point-of-care (POC) sensing platforms and implantable devices with special functionalities. In this review, the recent advances in biosensors for patient-friendly diagnosis and implantable devices for patient-friendly treatment are discussed. Comprehensive analysis of portable and wearable biosensing platforms for patient-friendly health monitoring and disease diagnosis is provided, including topics such as materials selection, device structure and integration, and biomarker detection strategies. Moreover, specific challenges related to each biological fluid for wearable biosensor-based POC applications are presented. Also, advances in implantable devices, including recent materials development and wireless communication strategies, are discussed. Furthermore, various patient-friendly surgical and treatment approaches are reviewed, such as minimally invasive insertion and mounting, in vivo electrical and optical modulations, and post-operation health monitoring. Finally, the challenges and future perspectives toward the development of the patient-friendly diagnosis and treatment are provided.
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