4.6 Article

A Structure-Based Discovery Platform for BACE2 and the Development of Selective BACE Inhibitors

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate

Ingrid C. Rulifson et al.

PLOS ONE (2016)

Article Multidisciplinary Sciences

Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice

Derya R. Shimshek et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

Inhibition of BACE2 counteracts hIAPP-induced insulin secretory defects in pancreatic β-cells

Gema Alcarraz-Vizan et al.

FASEB JOURNAL (2015)

Article Multidisciplinary Sciences

Amino Acid Sequence and Structural Comparison of BACE1 and BACE2 Using Evolutionary Trace Method

Hoda Mirsafian et al.

SCIENTIFIC WORLD JOURNAL (2014)

Article Biochemical Research Methods

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations

Yechun Xu et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2012)

Article Chemistry, Multidisciplinary

The Amyloid Formation Mechanism in Human IAPP: Dimers Have β-Strand Monomer-Monomer Interfaces

Nicholas F. Dupuis et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Article Biochemistry & Molecular Biology

Control of aggregation in protein refolding: The temperature-leap tactic

Yansheng Xie et al.

PROTEIN SCIENCE (2010)

Article Chemistry, Medicinal

Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors

Rainer Machauer et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

Article Biochemistry & Molecular Biology

Large Scale Refolding and Purification of the Catalytic Domain of Human BACE-2 Produced in E-coli

T. L. Emmons et al.

PROTEIN AND PEPTIDE LETTERS (2009)

Article Biochemistry & Molecular Biology

Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production

Hideaki Shimizu et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Chemistry, Medicinal

β-Secretase (BACE-1) inhibitors:: Accounting for 10s loop flexibility using rigid active sites

Georgia B. McGaughey et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

Article Chemistry, Medicinal

Macrocyclic inhibitors of β-secretase:: Functional activity in an animal model

Shawn J. Stachel et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor

N Ostermann et al.

JOURNAL OF MOLECULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

D Dominguez et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Chemistry, Medicinal

Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (β-secretase)

AK Ghosh et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)