Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 13, Issue 7, Pages 7987-7996Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c21309
Keywords
aggregation-induced emission; multifunctional nanoparticles; ultrafast monitoring; two-photon; image-guide photodynamic therapy
Funding
- National Natural Science Foundation of China [21788102, 51673107]
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The development of multifunctional photosensitizers with aggregation-induced emission properties is essential for advancing photodynamic therapy. In this study, a multifunctional PS named DSABBT NPs was designed and prepared to provide ultrafast staining, excellent two-photon bioimaging, and high-efficiency image-guided PDT. DSABBT NPs exhibited bright solid-state fluorescence, high two-photon absorption cross-section, fast staining and imaging capabilities, as well as efficient singlet oxygen generation and image-guided PDT efficiency. Overall, DSABBT NPs show promise as multifunctional photosensitizers for cancer treatment.
The development of multifunctional photosensitizers (PSs) with aggregation-induced emission (AIE) properties plays a critical role in promoting the progress of the photodynamic therapy (PDT). In this work, a multifunctional PS (named DSABBT NPs) with AIE activity has been designed and prepared to carry out ultrafast staining, excellent two-photon bioimaging, and high-efficiency image-guided PDT. Simply, DSABBT with AIE characteristic was synthesized by one-step Schiff reaction of 4-(diethylamino)-salicylaldehyde (DSA) and 4,7-bis(4-aminophenyl)-2,1,3-benzothiadiazole (BBT). Then, DSABBT and DSPE-PEG(2000)-cRGD generate nanoparticles (NPs) easily in an ultrapure water/tetrahydrofuran mixture through a facile nanoprecipitation at room temperature. We found that DSABBT NPs exhibit bright solid-state fluorescence with large stokes shifts (180 nm) and two-photon absorption cross-section (1700 GM). Importantly, DSABBT NPs exhibited excellent ability of ultrafast staining and two-photon imaging, which can readily label suborganelles by subtly shaking the living cells for 5 s under mild conditions. Moreover, DSABBT NPs displayed high singlet oxygen (O-1(2)) generation capacity and remarkable image-guided PDT efficiency. Therefore, DSABBT NPs can act as the promising candidate for multifunctional PSs, which can destroy cancer cells and block malignant tumor growth via the production of reactive oxygen species upon irradiation conditions. These outcomes provide us with a selectable strategy for developing multifunctional theranostic systems.
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