Journal
CHEMPHOTOCHEM
Volume 5, Issue 4, Pages 298-316Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cptc.202000253
Keywords
BODIPY; caging groups; coumarin; photoprotecting groups; photopharmacology; visible light
Categories
Funding
- European Union's Horizon2020 research and innovation programme under the Marie Sklodowska-Curie grant [841089]
- Ministerio de Ciencia e Innovacion, Agencia Estatal de Investigacion
- ERDF-FEDER European Fund [CTQ2017-89222-R, PCI2018-093047]
- Catalan government [2017 SGR 1604]
- Marie Curie Actions (MSCA) [841089] Funding Source: Marie Curie Actions (MSCA)
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Photopharmacological tools allow precise control of small molecule drugs through the release of active molecules under illumination. Recent developments have led to the design of caging groups that can be released under visible light, expanding the utility of these tools. This review outlines the chemical strategies used to increase absorption wavelengths and discusses their synthetic accessibility and biological applications.
Photopharmacological tools enable the precise spatiotemporal control of small molecule drugs. Amongst them, caged compounds incorporate a photolabile moiety which is released under illumination, thus liberating the active molecule. Caging groups have long been known and many chemical scaffolds have already been used in different applications. However, most of the initial examples are cleaved with UV light, which suffers from low tissue permeability and cell damage. Recently, caging groups that are released under visible light have been reported, which expand their utility. In this review, we outline the chemical strategies that have been used to increase the absorption wavelengths; we compare their photophysical properties, discuss their synthetic accessibility, and exemplify some of their biological applications.
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