Journal
LIFE-BASEL
Volume 11, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/life11010038
Keywords
secreted protein acidic and rich in cysteine; regeneration; homeostasis
Categories
Funding
- Ministry of Education and Higher Education of Quebec, Canada, The Fonds de recherche du QuebecNature et technologies (FRQNT)
Ask authors/readers for more resources
SPARC protein plays a crucial role in tissue regeneration by creating an environment suitable for tissue regeneration and enhancing tissue repair ability, with potential applications in various diseases and bioengineering.
Diverse pathologies (inflammation, tissues injuries, cancer, etc.) and physiological conditions (obesity, physical activity, etc.) induce the expression/secretion of the matricellular protein, secrete protein acidic and rich in cysteine (SPARC). SPARC contributes to the creation of an environment that is suitable for tissue regeneration through a variety of roles, including metabolic homeostasis, inflammation reduction, extracellular matrix remodeling and collagen maturation. Such a homeostatic environment optimizes tissue regeneration and improves tissues' repair ability. These properties that SPARC has within the regeneration contexts could have a variety of applications, such as in obesity, cancer, sarcopenia, diabetes and bioengineering.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available