Journal
LIFE-BASEL
Volume 11, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/life11010003
Keywords
osteoarthritis; articular cartilage; chondrocyte; synovium; synoviocyte; fibrosis
Categories
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2019R1I1A1A01060753]
- National Research Foundation of Korea (NRF) - Korea government (Ministry of Science and ICT, MSIT) [NRF-2020R1A1C3004123]
- Korea Healthcare Technology R&D project, Ministry for Health, Welfare and Family Affairs, Republic of Korea [HI16C2177]
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Osteoarthritis is a chronic degenerative joint disease characterized by cartilage degeneration and synovial membrane inflammation, which may eventually require joint replacement surgery. Joint fibrosis is a critical issue for understanding the disease, but the related characteristics are still largely misunderstood.
Osteoarthritis (OA) is a chronic degenerative joint disease where the main characteristics include cartilage degeneration and synovial membrane inflammation. These changes in the knee joint eventually dampen the function of the joint and restrict joint movement, which eventually leads to a stage where total joint replacement is the only treatment option. While much is still unknown about the pathogenesis and progression mechanism of OA, joint fibrosis can be a critical issue for better understanding this disease. Synovial fibrosis and the generation of fibrocartilage are the two main fibrosis-related characteristics that can be found in OA. However, these two processes remain mostly misunderstood. In this review, we focus on the fibrosis process in OA, especially in the cartilage and the synovium tissue, which are the main tissues involved in OA.
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