Journal
ENEURO
Volume 8, Issue 1, Pages -Publisher
SOC NEUROSCIENCE
DOI: 10.1523/ENEURO.0328-20.2020
Keywords
auditory; GABAergic; LY354740; mGluR2/3; neuromodulation; non-GABAergic
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Funding
- National Institutes of Health [R01 DC016918, R01 DC004391]
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The study showed that pharmacological activation of mGluR2/3 in the mouse IC resulted in increased sound-evoked firing in both GABAergic and non-GABAergic neurons, as well as elevated spontaneous excitability, indicating a widespread distribution of mGluR2/3 in the IC.
Little is known about the functions of Group II metabotropic glutamate receptors (mGluRs2/3) in the inferior colliculus (IC), a midbrain structure that is a major integration region of the central auditory system. We investigated how these receptors modulate sound-evoked and spontaneous firing in the mouse IC in vivo. We first performed immunostaining and tested hearing thresholds to validate vesicular GABA transporter (VGAT)-ChR2 transgenic mice on a mixed CBA/CaJ x C57BL/6J genetic background. Transgenic animals allowed for optogenetic cell-type identification. Extracellular single neuron recordings were obtained before and after pharmacological mGluR2/3 activation. We observed increased sound-evoked firing, as assessed by the rate-level functions (RLFs), in a subset of both GABAergic and non-GABAergic IC neurons following mGluR2/3 pharmacological activation. These neurons also displayed elevated spontaneous excitability and were distributed throughout the IC area tested, suggesting a widespread mGluR2/3 distribution in the mouse IC.
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