Journal
BIOLOGY-BASEL
Volume 10, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/biology10010043
Keywords
lignans; polyphenols; flaxseed extract; streptozotocin; antidiabetic effects
Categories
Funding
- BASTEURES Bast Plants-Renewable Strategic Resources for European Economy (2010-2013) project
- European Union
- Romanian Government through the European Regional Development Fund, the Sectoral Operational Programme Increase of Economic Competitiveness. Investing for your future, Operation O.2.1.2 CD project of high scientific level with the participation of forei
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Diabetes mellitus is a common metabolic condition affecting many people globally. The study investigated the enhanced activity of flaxseed lignans and polyphenols in diabetic rats induced with STZ, showing improved glycemic control and lipid profiles. Flaxseed extract administration led to positive changes in body weight, glucose levels, and various biochemical parameters in the treated rats, while histopathological observations supported the beneficial effects on organ function. The study suggests the potential therapeutic impact of polyphenols and lignans in diabetes management.
Simple Summary Diabetes mellitus is a metabolic condition that affects millions of people globally. The present study highlights the enhanced activity of flaxseed lignans and polyphenols isolated from Linum usitatissimum in streptozotocin (STZ)-induced diabetic rats. Treatment with flaxseed extract showed enhanced glycosylated hemoglobin and blood glucose levels and reduced plasma cholesterol, low-density lipoprotein (LDL) cholesterol and triglycerides, urea and uric acid intensities, and plasma creatinine in the treated diabetic experimental animals, indicating beneficial effects-results sustained by histopathological observations of liver, pancreas, kidney, and spleen. Translation of this nutraceutical-based approach still requires further elucidation of its mechanism of action toward clinical applications. Flaxseeds play an important role in human health due to their chemical composition and recognized beneficial outcomes. This study investigated the antidiabetic effects of present lignans and polyphenols found in the flaxseed extract on streptozotocin (STZ)-induced diabetic rats. The flaxseed administration produced favorable changes in body weight, food and water intake, and glycosylated hemoglobin and blood glucose quantities in the treated diabetic rats. Additionally, significant positive results were observed in the biochemical parameters, namely reduced plasma cholesterol, LDL cholesterol and triglycerides, plasma creatinine, and urea and uric acid levels, highlighting the seeds' use in traditional medicine. The results were sustained by histopathological observations that showed better tissue preservation following the flaxseed diet. Overall, the consumption of flaxseeds produced moderate reduction in glucose levels and hyperlipidemia, together with improvement in the impaired organs' function in diabetic rats. The daily administration of polyphenols and lignans compounds could impact therapeutic potential in diabetes management.
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