Spatial clustering of orientation preference in primary visual cortex of the large rodent agouti

All rodents investigated so far possess orientation-selective neurons in the primary visual cortex (V1) but - in contrast to carnivores and primates - no evidence of periodic maps with pinwheel-like structures. Theoretical studies debating whether phylogeny or universal principles determine development of pinwheels point to V1 size as a critical constraint. Thus, we set out to studymaps of agouti, a big diurnal rodent with a V1 size comparable to cats'. In electrophysiology, we detected interspersed orientation and direction-selective neurons with a bias for horizontal contours, corroborated by homogeneous activation in optical imaging. Compatible with spatial clustering at short distance, nearby neurons tended to exhibit similar orientation preference. Our results argue against V1 size as a key parameter in determining the presence of periodic orientation maps. They are consistent with a phylogenetic influence on the map layout and development, potentially reflecting distinct retinal traits or interspecies differences in cortical circuitry.

Automated summary

Research has shown that rodents possess orientation and direction-selective neurons in the V1 region, but do not exhibit periodic orientation maps as seen in other animals. The size of the V1 region is not a determining factor for the presence of periodic orientation maps, indicating a potential phylogenetic influence on the layout and development of these maps.