Journal
BIOMEDICINES
Volume 8, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines8120568
Keywords
epigenetics; histone deacetylase inhibitors; flavones; molecular simulations
Categories
Funding
- VALERE: Vanvitelli per la Ricerca
- Campania Regional Government Technology Platform Lotta alle Patologie Oncologiche [iCURE-B21C17000030007]
- Campania Regional Government FASE2: IDEAL
- MIUR, Proof of Concept [EPICUREPOC01_00043-B64I19000290008]
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Histone modifications through acetylation are fundamental for remodelling chromatin and consequently activating gene expression. The imbalance between acetylation and deacetylation activity causes transcriptional dysregulation associated with several disorders. Flavones, small molecules of plant origin, are known to interfere with class I histone deacetylase (HDAC) enzymes and to enhance acetylation, restoring cell homeostasis. To investigate the possible physical interactions of flavones on human HDAC1 and 2, we carried out in silico molecular docking simulations. Our data have revealed how flavone, and other two flavones previously investigated, i.e., apigenin and luteolin, can interact as ligands with HDAC1 and 2 at the active site binding pocket. Regulation of HDAC activity by dietary flavones could have important implications in developing epigenetic therapy to regulate the cell gene expression.
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