Journal
BIOMEDICINES
Volume 9, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines9020115
Keywords
thyroid diseases; endocrine disruptor compound; human umbilical artery; vascular homeostasis
Categories
Funding
- FEDER funds through the POCI-COMPETE 2020-Operational Program Competitiveness and Internationalisation in Axis I-Strengthening research, technological development and innovation [POCI-01-0145-FEDER007491]
- National Funds by FCT-Foundation for Science and Technology [UID/Multi/00709/2019]
- European Regional Development Fund through the Programa Operacional Regional do Centro (Centro 2020)-Sistema de Apoio a Investigacao Cientifica e Tecnologica-Programas Integrados de ICDT [Centro-01-0145-FEDER-000019-C4]
- FCT [2020.06616.BD]
- FCT-Fundacao para a Ciencia e a Tecnologia, I.P.
- FCT/MCTES [UIDB/50017/2020 + UIDP/50017/2020]
- Fundação para a Ciência e a Tecnologia [2020.06616.BD] Funding Source: FCT
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The study examined the effects of OMC on arterial tonus in pregnant women with hypothyroidism, indicating a possible interference with HUA contraction patterns and increased risk of cardiovascular diseases.
Increasing evidence relating the exposure and/or bioaccumulation of endocrine-disrupting compounds (EDCs) with cardiovascular system are arising. Octylmethoxycinnamate (OMC) is the most widely used UV-B filter and as EDC interacts with TH receptors. However, their effects on thyroid diseases during pregnancy remain unknown. The purpose of this work was to assess the short- and long-term effects of OMC on arterial tonus of pregnant women with hypothyroidism. To elucidate this, human umbilical artery (HUA) rings without endothelium were used to explore the vascular effects of OMC by arterial and cellular experiments. The binding energy and the modes of interaction of the OMC into the active center of the TSHR and THR alpha were analyzed by molecular docking studies. Our results indicated that OMC altered the contractility patterns of HUA contracted with serotonin, histamine and KCl, possibly due to an interference with serotonin and histamine receptors or an involvement of the Ca2+ channels. The molecular docking analysis show that OMC compete with T-3 for the binding center of THR alpha. Taken together, these findings pointed out to alterations in HUA reactivity as result of OMC-exposure, which may be involved in the development and increased risk of cardiovascular diseases.
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