Journal
BRAIN SCIENCES
Volume 10, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/brainsci10110885
Keywords
hydrocortisone; neonatal seizure; neuronal inflammation; neonatal status epilepticus
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Neonatal seizures are the most common neurological emergency, and neonatal status epilepticus (NSE) remains a controversial entity, with no general consensus about its definition and treatment. Here, we report on three newborns with NSE refractory to first- and second-line antiepileptic drugs successfully treated with intravenous (IV) hydrocortisone. The patients had previously failed therapy with levetiracetam, phenobarbital and midazolam, showing persistent clinical and electrical seizures. Modulation of brain inflammation triggered during prolonged epileptic activity has been thought to potentially explain the beneficial effects of anti-inflammatory treatment.
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