Journal
BRAIN SCIENCES
Volume 10, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/brainsci10120946
Keywords
tau; DNA damage; Alzheimer's disease
Categories
Funding
- Brigthfocus Grant [A2019296F]
- Associazione Italiana per la Ricerca sul Cancro (AIRC) [IG21806]
- Telethon [GGP15227]
- MIUR [PRIN-2017KSZZJW_002]
- Finanziamento Linea 2-Universita degli studi di Milano
- Fondo di Beneficenza-Gruppo Intesa Sanpaolo
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Neurodegenerative disorders are a family of incurable conditions. Among them, Alzheimer's disease and tauopathies are the most common. Pathological features of these two disorders are synaptic loss, neuronal cell death and increased DNA damage. A key pathological protein for the onset and progression of the conditions is the protein tau, a microtubule-binding protein highly expressed in neurons and encoded by the MAPT (microtubule-associated protein tau) gene. Tau is predominantly a cytosolic protein that interacts with numerous other proteins and molecules. Recent findings, however, have highlighted new and unexpected roles for tau in the nucleus of neuronal cells. This review summarizes the functions of tau in the metabolism of DNA, describing them in the context of the disorders.
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