4.6 Review

Characteristics, Management and Outcomes of Spondylodiscitis in Children: A Systematic Review

Journal

ANTIBIOTICS-BASEL
Volume 10, Issue 1, Pages -

Publisher

MDPI
DOI: 10.3390/antibiotics10010030

Keywords

spondylodiscitis; discitis; vertebral osteomyelitis; children; pediatric; antibiotic therapy

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This study systematically reviewed the main features of pediatric SD, highlighting significant gaps in the literature on this topic. The most frequently affected age group, affected site, symptoms, and commonly identified pathogen and treatment strategies were summarized, providing important insights into the current understanding of pediatric SD.
Spondylodiscitis (SD) is the concurrent infection of the intervertebral disc and the adjacent vertebral bodies. Currently, there is a substantial lack of structured reviews about this topic. The aim of this study was to systematically review the available literature in order to determine the main features of pediatric SD. A systematic search of MEDLINE database was performed, according to the PRISMA guideline recommendations. Clinical features, laboratory data, radiological signs, treatments strategies, and outcomes were summarized. Studies' quality assessments were performed using the JBI Critical Appraisal Checklists. A total of 35 retrospective studies were analyzed and 340 children were identified. The most frequently affected age class was 0.5-4 years. The most affected site was the lumbar spine. The most commonly reported symptoms were back pain (37.97%) and refusal to walk/to stand/to sit (49.79%). The most frequently identified pathogen was Staphylococcus aureus (n = 33). The most used antibiotics were third generation cephalosporins. The intravenous therapy duration range was 1-25 weeks, the oral therapy duration range was 5 days-36 months. Surgery was used in 5.88% of children. In 29 cases clinical sequelae were documented. This study provides the main features of pediatric SD; it also emphasizes the significant gaps in the literature regarding this topic.

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