Journal
METABOLITES
Volume 10, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/metabo10120478
Keywords
glioma; metabolomics; lipidomics; grading; short-chain acylcarnitines; lysophosphatidylethanolamines
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Funding
- National Natural Science Foundation of China [21934006, 21705147]
- National Key Research and Development Program of China [2019YFC1605100]
- Innovation Program of Science and Research from Dalian Institute of Chemical Physics, Chinese Academy of Sciences [DICP I202019, DICP TMSR201601]
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Gliomas are the most aggressive phenotypes of brain tumors and are classified into four grades according to the malignancy degree by the World Health Organization. Metabolic profiling can provide an overview of metabolic reprogramming at a specific stage of tumor initiation and development. Studies about metabolic alterations related to different grades of gliomas are helpful to understand the molecular mechanism for progression of glioma. In the current study, metabolomics and lipidomics analyses based on chromatography-mass spectrometry were performed on different grades of glioma tissues. Differential metabolites between glioma and para-tumor tissues were studied and used as the basis to explore metabolic alterations related to glioma grading. It was found that short-chain acylcarnitines were elevated, whereas lysophosphatidylethanolamines (LPEs) were decreased in high-grade gliomas. Furthermore, the gene expression of short/branched-chain acyl-coenzyme dehydrogenase (ACADSB), which is involved in fatty acid oxidation, was found down-regulated with glioma progression by analyzing related genes and pathways. In addition, LPE metabolism showed a significant difference among different grades of gliomas. These important metabolic pathways related to glioma progression may provide potential clues for further study on the mechanisms and treatment of glioma.
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