Journal
PATHOGENS
Volume 10, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/pathogens10020096
Keywords
polymicrobial infection; host-pathogen interface; pathogen; commensal; bacterial interactions
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Funding
- NIH/NIGMS [R15GM128072]
- Texas Tech University Graduate School
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This review explores how microbial interactions shape host health, with both competitive and cooperative interactions potentially having positive or negative effects on the host.
The human microbiota is an array of microorganisms known to interact with the host and other microbes. These interactions can be competitive, as microbes must adapt to host- and microorganism-related stressors, thus producing toxic molecules, or cooperative, whereby microbes survive by maintaining homeostasis with the host and host-associated microbial communities. As a result, these microbial interactions shape host health and can potentially result in disease. In this review, we discuss these varying interactions across microbial species, their positive and negative effects, the therapeutic potential of these interactions, and their implications on our knowledge of human well-being.
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