4.6 Review

A Revisit to the Research Updates of Drugs, Vaccines, and Bioinformatics Approaches in Combating COVID-19 Pandemic

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Designing a multi-epitope vaccine against SARS-CoV-2: an immunoinformatics approach

Abdus Samad et al.

Summary: The ongoing COVID-19 outbreak poses a significant challenge to global public health security. In this study, a multi-epitope vaccine against SARS-CoV-2 was designed using an immunoinformatics approach. The vaccine showed antigenicity, immunogenicity, and non-allergenicity, with suitable physicochemical properties. Molecular dynamics simulation and immune simulation demonstrated the effectiveness of the vaccine, and codon optimization was performed. This designed peptide vaccine has the potential to be an excellent prophylactic candidate against SARS-CoV-2.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

Article Biochemistry & Molecular Biology

Peptide-like and small-molecule inhibitors against Covid-19

Suyash Pant et al.

Summary: The study identified potential protease inhibitors against SARS-CoV-2 using computational approaches, screening compounds from various databases and conducting docking and molecular dynamics simulations to find promising drugs.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Article Biochemistry & Molecular Biology

Identification of potential molecules against COVID-19 main protease through structure-guided virtual screening approach

Lovika Mittal et al.

Summary: The COVID-19 pandemic has driven the search for rapid therapeutic strategies, with in-silico techniques being used to repurpose existing drugs and molecules to identify potential candidates. This approach has led to the discovery of several promising drug candidates, including anti-protease molecules, that show significant potential as inhibitors of the main protease of the novel coronavirus.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Article Biochemistry & Molecular Biology

An in-silico evaluation of different Saikosaponins for their potency against SARS-CoV-2 using NSP15 and fusion spike glycoprotein as targets

Saurabh K. Sinha et al.

Summary: The study investigated the potential of Saikosaponins in inhibiting SARS-CoV-2 by conducting computational molecular docking simulations. Saikosaponins U and V showed promising affinity towards key proteins involved in viral replication and host cell entry, suggesting them as potential candidates for further research and development.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Article Biochemistry & Molecular Biology

SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective

Abdo A. Elfiky

Summary: This study used molecular modeling and dynamics simulations to test the binding affinity of various clinically approved drugs and drug candidates to SARS-CoV-2 RdRp. The results showed that several drugs demonstrated effective binding, with Setrobuvir, YAK and IDX-184 showing particularly promising results.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Article Biochemistry & Molecular Biology

In silico study the inhibition of angiotensin converting enzyme 2 receptor of COVID-19 by Ammoides verticillata components harvested from Western Algeria

Imane Abdelli et al.

Summary: The study focuses on screening an alternative drug to block ACE2 activity as a receptor for SARS-CoV-2, with Isothymol from Ammoides verticillata showing the best docking scores. This study suggests that Isothymol and other natural compounds could be potential inhibitors for the ACE2 receptor of SARS-CoV-2.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Article Biochemistry & Molecular Biology

Drug repurposing for coronavirus (COVID-19): in silico screening of known drugs against coronavirus 3CL hydrolase and protease enzymes

Ammar D. Elmezayen et al.

Summary: This study attempted to identify commercially available drugs for repurposing against coronavirus through structure-based virtual screening, successfully finding multiple potential inhibitors. The 3D structure of TMPRSS2 was generated using homology modeling, and promising inhibitors were identified through docking studies. ADMET profiles showed that the compounds discovered in the study are safe and drug-like.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Article Biochemistry & Molecular Biology

In-silicoapproaches to detect inhibitors of the human severe acute respiratory syndrome coronavirus envelope protein ion channel

Manoj Kumar Gupta et al.

Summary: This study investigated the structure, function, and interaction of the human SARS-CoV2 E protein with phytochemicals using computational methods. The results showed that certain phytochemicals can inhibit the protein's function, potentially serving as drugs to control diseases caused by SARS-CoV2.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Article Biochemistry & Molecular Biology

Reverse vaccinology approach to design a novel multi-epitope vaccine candidate against COVID-19: an in silico study

Maryam Enayatkhani et al.

Summary: This study utilized bioinformatics approaches to design a novel multi-epitope vaccine against the novel Coronavirus, potentially triggering multiple immune responses. Computational tools were used to validate the biological activities of the vaccine, predict the binding of the protein candidate with Toll-like receptor 4 and HLA-A*11:01, and molecular dynamics simulation was employed to evaluate the stability of the designed fusion protein with the receptors.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Article Biochemistry & Molecular Biology

In-silico homology assisted identification of inhibitor of RNA binding against 2019-nCoV N-protein (N terminal domain)

Phulen Sarma et al.

Summary: This study targeted the RNA-binding N terminal domain of the N protein of coronavirus to identify possible inhibitors of RNA binding. Theophylline and pyrimidone derivatives were identified as potential inhibitors, opening up new avenues for in vitro validations of their RNA binding inhibition capabilities.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Editorial Material Gastroenterology & Hepatology

Evidence for Gastrointestinal Infection of SARS-CoV-2

Fei Xiao et al.

GASTROENTEROLOGY (2020)

Article Medicine, General & Internal

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China

Dawei Wang et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

Article Multidisciplinary Sciences

A new coronavirus associated with human respiratory disease in China

Fan Wu et al.

NATURE (2020)

Article Medicine, General & Internal

Clinical Characteristics of Coronavirus Disease 2019 in China

W. Guan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

First Case of 2019 Novel Coronavirus in the United States

Michelle L. Holshue et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

A Novel Coronavirus from Patients with Pneumonia in China, 2019

Na Zhu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Multidisciplinary Sciences

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Daniel Wrapp et al.

SCIENCE (2020)

Editorial Material Medicine, General & Internal

Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know

Jinoos Yazdany et al.

ANNALS OF INTERNAL MEDICINE (2020)

Review Microbiology

Updated Approaches against SARS-CoV-2

Haiou Li et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

Review Chemistry, Physical

Molecular Dynamics Simulation of Small Molecules Interacting with Biological Membranes

Carlo Martinotti et al.

CHEMPHYSCHEM (2020)

Article Immunology

Antibody Responses to SARS-CoV-2 in Patients With Novel Coronavirus Disease 2019

Juanjuan Zhao et al.

CLINICAL INFECTIOUS DISEASES (2020)

Editorial Material Respiratory System

Pathogenesis of COVID-19 from a cell biology perspective

Robert J. Mason

EUROPEAN RESPIRATORY JOURNAL (2020)

Review Immunology

SARS-CoV-2 Vaccines: Status Report

Fatima Amanat et al.

IMMUNITY (2020)

Article Infectious Diseases

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

Philippe Gautret et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

Article Infectious Diseases

Three cases of treatment with nafamostat in elderly patients with COVID-19 pneumonia who need oxygen therapy

Sukbin Jang et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

Review Medicine, General & Internal

Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19) A Review

James M. Sanders et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Multidisciplinary Sciences

Effective treatment of severe COVID-19 patients with tocilizumab

Xiaoling Xu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Infectious Diseases

COVID-19 spike-host cell receptor GRP78 binding site prediction

Ibrahim M. Ibrahim et al.

JOURNAL OF INFECTION (2020)

News Item Multidisciplinary Sciences

Vaccine designers take first shots at COVID-19

Jon Cohen

SCIENCE (2020)

Article Multidisciplinary Sciences

Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model

Barry Rockx et al.

SCIENCE (2020)

Review Virology

Virology, Epidemiology, Pathogenesis, and Control of COVID-19

Yuefei Jin et al.

VIRUSES-BASEL (2020)

Review Biotechnology & Applied Microbiology

A Review on the Novel Coronavirus Disease based on In-silico Analysis of Various Drugs and Target Proteins

Gauravi N. Trivedi et al.

JOURNAL OF PURE AND APPLIED MICROBIOLOGY (2020)

Article Public, Environmental & Occupational Health

A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease

Donald C. Hall et al.

TRAVEL MEDICINE AND INFECTIOUS DISEASE (2020)

Article Public, Environmental & Occupational Health

Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France

Matthieu Million et al.

TRAVEL MEDICINE AND INFECTIOUS DISEASE (2020)

Editorial Material Microbiology

Ivermectin, a new candidate therapeutic against SARS-CoV-2/COVID-19

Khan Sharun et al.

ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS (2020)

Review Biotechnology & Applied Microbiology

COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics

Kuldeep Dhama et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2020)

News Item Multidisciplinary Sciences

THE RACE FOR CORONAVIRUS VACCINES

Ewen Callaway

NATURE (2020)

News Item Biotechnology & Applied Microbiology

The pandemic pipeline

John Hodgson

NATURE BIOTECHNOLOGY (2020)

Editorial Material Biotechnology & Applied Microbiology

The COVID-19 vaccine development landscape

Tung Thanh Le et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Engineering, Multidisciplinary

Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study

Qingxian Cai et al.

ENGINEERING (2020)

Article Medicine, General & Internal

Remdesivir for the Treatment of Covid-19-Final Report

John H. Beigel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Compassionate Use of Remdesivir for Patients with Severe Covid-19

J. Grein et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Pharmacology & Pharmacy

Structural basis of SARS-CoV-2 3CL(pro) and anti-COVID-19 drug discovery from medicinal plants

Muhammad Tahir ul Qamar et al.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2020)

Review Pharmacology & Pharmacy

Molecular immune pathogenesis and diagnosis of COVID-19

Xiaowei Li et al.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2020)

Article Pharmacology & Pharmacy

Delayed Initiation of Remdesivir in a COVID-19-Positive Patient

Emily Hillaker et al.

PHARMACOTHERAPY (2020)

Article Pharmacology & Pharmacy

Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

Ka-Tim Choy et al.

ANTIVIRAL RESEARCH (2020)

Review Infectious Diseases

The pathogenesis and treatment of the 'Cytokine Storm' in COVID-19

Qing Ye et al.

JOURNAL OF INFECTION (2020)

Article Medicine, Research & Experimental

In silico studies on therapeutic agents for COVID-19: Drug repurposing approach

Bhumi Shah et al.

LIFE SCIENCES (2020)

Article Medicine, General & Internal

A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19

David R. Boulware et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

An mRNA Vaccine against SARS-CoV-2-Preliminary Report

L. A. Jackson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Pharmacology & Pharmacy

Update on therapeutic approaches and emerging therapies for SARS-CoV-2 virus

Calvin A. Omolo et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Review Infectious Diseases

Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2)-an update on the status

Tarek Mohamed Abd El-Aziz et al.

INFECTION GENETICS AND EVOLUTION (2020)

Review Microbiology

SARS-CoV-2/COVID-19 and advances in developing potential therapeutics and vaccines to counter this emerging pandemic

Ali A. Rabaan et al.

ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS (2020)

Article Infectious Diseases

Reverse vaccinology assisted designing of multiepitope-based subunit vaccine against SARS-CoV-2

Muhammad Tahir ul Qamar et al.

INFECTIOUS DISEASES OF POVERTY (2020)

Article Parasitology

Coagulation modifiers targeting SARS-CoV-2 main protease Mpro for COVID-19 treatment: an in silico approach

Isis Venturi Biembengut et al.

MEMORIAS DO INSTITUTO OSWALDO CRUZ (2020)

Article Infectious Diseases

The SARS-CoV-2 Vaccine Pipeline: an Overview

Wen-Hsiang Chen et al.

CURRENT TROPICAL MEDICINE REPORTS (2020)

Review Emergency Medicine

COVID-19: A review of therapeutics under investigation

James C. Crosby et al.

JOURNAL OF THE AMERICAN COLLEGE OF EMERGENCY PHYSICIANS OPEN (2020)

Review Infectious Diseases

A short review on antibody therapy for COVID-19

G. Venkat Kumar et al.

NEW MICROBES AND NEW INFECTIONS (2020)

Article Pharmacology & Pharmacy

Discovering drugs to treat coronavirus disease 2019 (COVID-19)

Liying Dong et al.

DRUG DISCOVERIES AND THERAPEUTICS (2020)

Review Allergy

Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19)

Balamurugan Shanmugaraj et al.

ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY (2020)

Review Biology

Potentials of plant-based substance to inhabit and probable cure for the COVID-19

Israt Jahan et al.

TURKISH JOURNAL OF BIOLOGY (2020)

Article Oncology

IN Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors

Heba E. Hashem

EURASIAN JOURNAL OF MEDICINE AND ONCOLOGY (2020)

Article Integrative & Complementary Medicine

In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus

Deng-hai Zhang et al.

JOURNAL OF INTEGRATIVE MEDICINE-JIM (2020)

Article Public, Environmental & Occupational Health

Clinical trials on drug repositioning for COVID-19 treatment

Sandro G. Viveiros Rosa et al.

REVISTA PANAMERICANA DE SALUD PUBLICA-PAN AMERICAN JOURNAL OF PUBLIC HEALTH (2020)

Article Medicine, General & Internal

Statins and the COVID-19 main protease: in silico evidence on direct interaction

Zeljko Reiner et al.

ARCHIVES OF MEDICAL SCIENCE (2020)

Article Medicine, General & Internal

A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics

Sabue Mulangu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Editorial Material Immunology

Oseltamivir Treatment of Influenza in Children

Timothy M. Uyeki

CLINICAL INFECTIOUS DISEASES (2018)

Article Biochemical Research Methods

Principles of vaccine potency assays

Thorsten Verch et al.

BIOANALYSIS (2018)

Article Pharmacology & Pharmacy

On the Integration of In Silico Drug Design Methods for Drug Repurposing

Eric March-Vila et al.

FRONTIERS IN PHARMACOLOGY (2017)

Article Medicine, General & Internal

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Mervyn Singer et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

Article Pharmacology & Pharmacy

Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model

Lisa Oestereich et al.

ANTIVIRAL RESEARCH (2014)

Review Pharmacology & Pharmacy

Big data in biomedicine

Fabricio F. Costa

DRUG DISCOVERY TODAY (2014)

Review Materials Science, Coatings & Films

Molecular dynamics simulation of atomic friction: A review and guide

Yalin Dong et al.

JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A (2013)

Article Chemistry, Multidisciplinary

In silico applications of bioisosterism in contemporary medicinal chemistry practice

George Papadatos et al.

WILEY INTERDISCIPLINARY REVIEWS-COMPUTATIONAL MOLECULAR SCIENCE (2013)

Review Biochemistry & Molecular Biology

Challenges and advances in computational docking: 2009 in review

Elizabeth Yuriev et al.

JOURNAL OF MOLECULAR RECOGNITION (2011)

Article Computer Science, Information Systems

Informatics and medicine - From molecules to populations

K. A. Kuhn et al.

METHODS OF INFORMATION IN MEDICINE (2008)

Article Virology

Human immunopathogenesis of severe acute respiratory syndrome (SARS)

Mark J. Cameron et al.

VIRUS RESEARCH (2008)

Review Infectious Diseases

Recycling of chloroquine and its hydroxyl analogue to face bacterial, fungal and viral infections in the 21st century

Jean-Marc Rolain et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2007)

Article Chemistry, Medicinal

Analysis of HIV wild-type and mutant structures via in silico docking against diverse ligand libraries

Max W. Chang et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2007)

Review Pharmacology & Pharmacy

In silico pharmacology for drug discovery: applications to targets and beyond

S. Ekins et al.

BRITISH JOURNAL OF PHARMACOLOGY (2007)

Letter Infectious Diseases

New insights into the antiviral effects of chloroquine

A Savarino et al.

LANCET INFECTIOUS DISEASES (2006)

Review Medicine, General & Internal

SARS: Systematic review of treatment effects

Lauren J. Stockman et al.

PLOS MEDICINE (2006)

Article Critical Care Medicine

Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome

Y Jiang et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2005)

Review Pharmacology & Pharmacy

Predicting ADME properties in silico:: methods and models

D Butina et al.

DRUG DISCOVERY TODAY (2002)