Journal
ANTIOXIDANTS
Volume 9, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/antiox9121211
Keywords
oxidative stress; antioxidant; periodontal disease; oral cavity; inflammation; oxidants
Funding
- Taipei Medical University Hospital [109TMU-TMUH-16]
- Ministry of Science and Technology, Taiwan [MOST 109-2320-B-039-021]
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There is growing evidence on the involvement of oxidative stress, which is simply described as the imbalance between oxidants and antioxidants in favor of the former, in the development of periodontal disease that is the most common inflammatory disease in the oral cavity. Thus, the potential of antioxidant phytochemicals as adjunctively preventive and therapeutic agents against the initiation and progression of periodontal disease is a topic of great interest. The current review firstly aims to provide updated insights about the immuno-inflammatory pathway regulated by oxidative stress in periodontal pathology. Then, this work further presents the systemic knowledge of antioxidant phytochemicals, particularly the pharmacological activities, which can be utilized in the prevention and treatment of periodontal disease. Additionally, the challenges and future prospects regarding such a scope are figured out.
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