4.7 Review

Thioredoxin and Glutaredoxin Systems as Potential Targets for the Development of New Treatments in Friedreich's Ataxia

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Safety and Efficacy of Omaveloxolone in Friedreich Ataxia (MOXIe Study)

David R. Lynch et al.

Summary: Omaveloxolone significantly improved neurological function in patients with FA, showing good safety and tolerability. It represents a potential therapeutic agent for FA.

ANNALS OF NEUROLOGY (2021)

Review Pharmacology & Pharmacy

Melatonin as a potential modulator of Nrf2

Zahra Ahmadi et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2020)

Review Biochemistry & Molecular Biology

Mechanisms of Mitochondrial Iron-Sulfur Protein Biogenesis

Roland Lill et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 89 (2020)

Review Biochemistry & Molecular Biology

The NRF2 Signaling Network Defines Clinical Biomarkers and Therapeutic Opportunity in Friedreich's Ataxia

Piergiorgio La Rosa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

Fulvio Ursini et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Review Biochemistry & Molecular Biology

Hereditary Ataxia: A Focus on Heme Metabolism and Fe-S Cluster Biogenesis

Deborah Chiabrando et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death

Eduardo Balsa et al.

NATURE COMMUNICATIONS (2020)

Review Neurosciences

Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases

Xiaohua Song et al.

FRONTIERS IN NEUROSCIENCE (2020)

Review Biochemistry & Molecular Biology

Oxidative Stress in DNA Repeat Expansion Disorders: A Focus on NRF2 Signaling Involvement

Piergiorgio La Rosa et al.

BIOMOLECULES (2020)

Review Neurosciences

The Potential Value of Targeting Ferroptosis in Early Brain Injury After Acute CNS Disease

Junhui Chen et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)

Review Biochemistry & Molecular Biology

Cellular Mechanisms of Melatonin: Insight from Neurodegenerative Diseases

Dongmei Chen et al.

BIOMOLECULES (2020)

Review Biochemistry & Molecular Biology

Antioxidant Therapies and Oxidative Stress in Friedreich's Ataxia: The Right Path or Just a Diversion?

Laura R. Rodriguez et al.

ANTIOXIDANTS (2020)

Article Food Science & Technology

Melatonin induced suppression of ER stress and mitochondrial dysfunction inhibited NLRP3 inflammasome activation in COPD mice

Sushweta Mahalanobish et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

Review Neurosciences

Ferroptosis in Neurological Diseases

Jia-Xin Ren et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

Article Multidisciplinary Sciences

Molecular basis for the distinct functions of redox-active and FeS-transfering glutaredoxins

Daniel Trnka et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms

Lei Yang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Medicine, Research & Experimental

Inhibition of Glutaredoxin 5 predisposes Cisplatin-resistant Head and Neck Cancer Cells to Ferroptosis

Jaewang Lee et al.

THERANOSTICS (2020)

Review Biochemistry & Molecular Biology

Selenium: Tracing Another Essential Element of Ferroptotic Cell Death

Marcus Conrad et al.

CELL CHEMICAL BIOLOGY (2020)

Article Chemistry, Multidisciplinary

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

Evijola Llabani et al.

NATURE CHEMISTRY (2019)

Article Neurosciences

Nrf2 Induction Re-establishes a Proper Neuronal Differentiation Program in Friedreich's Ataxia Neural Stem Cells

Piergiorgio La Rosa et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

Article Biochemistry & Molecular Biology

Targeting NRF2 for the Treatment of Friedreich's Ataxia: A Comparison among Drugs

Sara Petrillo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Cell Biology

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Lian-Jiu Su et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Review Biochemistry & Molecular Biology

The role of oxidative stress in Friedreich's ataxia

Federica Lupoli et al.

FEBS LETTERS (2018)

Review Biochemistry & Molecular Biology

GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues

Matilde Maiorino et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Review Clinical Neurology

Progress in the treatment of Friedreich ataxia

Geneieve Tai et al.

NEUROLOGIA I NEUROCHIRURGIA POLSKA (2018)

Article Neurosciences

Novel Nrf2-Inducer Prevents Mitochondrial Defects and Oxidative Stress in Friedreich's Ataxia Models

Rosella Abeti et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Article Chemistry, Multidisciplinary

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

Ron Shah et al.

ACS CENTRAL SCIENCE (2018)

Article Biochemistry & Molecular Biology

Glutathione peroxidase 4: a new player in neurodegeneration?

B. R. Cardoso et al.

MOLECULAR PSYCHIATRY (2017)

Article Biochemistry & Molecular Biology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan et al.

NATURE CHEMICAL BIOLOGY (2017)

Review Clinical Neurology

Pharmacological therapeutics in Friedreich ataxia: the present state

Cassandra Strawser et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2017)

Article Biochemistry & Molecular Biology

Frataxin deficiency impairs mitochondrial biogenesis in cells, mice and humans

Mittal J. Jasoliya et al.

HUMAN MOLECULAR GENETICS (2017)

Article Biochemistry & Molecular Biology

Nrf2-Inducers Counteract Neurodegeneration in Frataxin-Silenced Motor Neurons: Disclosing New Therapeutic Targets for Friedreich's Ataxia

Sara Petrillo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Biochemistry & Molecular Biology

Ferroptosis and cell death mechanisms in Parkinson's disease

Stephanie J. Guiney et al.

NEUROCHEMISTRY INTERNATIONAL (2017)

Review Cell Biology

Cell Signaling with Extracellular Thioredoxin and ThioredoxinLike Proteins: Insight into Their Mechanisms of Action

Thierry Leveillard et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Review Clinical Neurology

Pharmacological therapeutics in Friedreich ataxia: the present state

Cassandra Strawser et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2017)

Review Biochemistry & Molecular Biology

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell et al.

Article Biochemistry & Molecular Biology

Lipid peroxidation in cell death

Michael M. Gaschler et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Geriatrics & Gerontology

Resveratrol Decreases TXNIP mRNA and Protein Nuclear Expressions With an Arterial Function Improvement in Old Mice

Tatiana Bedarida et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2016)

Review Biochemistry & Molecular Biology

Oxidation of NADH and ROS production by respiratory complex I

Andrei D. Vinogradov et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2016)

Letter Clinical Neurology

Tissue atrophy and elevated iron concentration in the extrapyramidal motor system in Friedreich ataxia: the IMAGE-FRDA study

Ian H. Harding et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2016)

Review Cell Biology

Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality?

Christine A. Houghton et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Article Multidisciplinary Sciences

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Wan Seok Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Biochemistry & Molecular Biology

TrxR1 as a Potent Regulator of the Nrf2-Keap1 Response System

Marcus Cebula et al.

ANTIOXIDANTS & REDOX SIGNALING (2015)

Article Multidisciplinary Sciences

Identification of the Mitochondrial Heme Metabolism Complex

Amy E. Medlock et al.

PLOS ONE (2015)

Article Multidisciplinary Sciences

Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols

Auberie Parent et al.

NATURE COMMUNICATIONS (2015)

Review Biochemistry & Molecular Biology

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

John D. Hayes et al.

TRENDS IN BIOCHEMICAL SCIENCES (2014)

Review Biochemistry & Molecular Biology

The Thioredoxin System as a Therapeutic Target in Human Health and Disease

Dler Faieeq Darweesh Mahmood et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Review Biochemistry & Molecular Biology

Nuclear glutathione

Jose Luis Garcia-Gimenez et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2013)

Article Biochemistry & Molecular Biology

Lafora disease fibroblasts exemplify the molecular interdependence between thioredoxin 1 and the proteasome in mammalian cells

Jose Luis Garcia-Gimenez et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Article Biochemistry & Molecular Biology

Frataxin Deficiency Leads to Reduced Expression and Impaired Translocation of NF-E2-Related Factor (Nrf2) in Cultured Motor Neurons

Valentina D'Oria et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Review Biochemistry & Molecular Biology

Diabetes in Friedreich Ataxia

Miriam Cnop et al.

JOURNAL OF NEUROCHEMISTRY (2013)

Review Clinical Neurology

Friedreich Ataxia: Neuropathology Revised

Arnulf H. Koeppen et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2013)

Article Neurosciences

Iron-sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia

Rachael A. Vaubel et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2013)

Review Cell Biology

Neurodegeneration in Friedreich's Ataxia: From Defective Frataxin to Oxidative Stress

Claudio M. Gomes et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)

Review Biochemistry & Molecular Biology

Thioredoxin System in Cell Death Progression

Jun Lu et al.

ANTIOXIDANTS & REDOX SIGNALING (2012)

Article Biochemistry & Molecular Biology

Changes in mitochondrial glutathione levels and protein thiol oxidation in Δyfh1 yeast cells and the lymphoblasts of patients with Friedreich's ataxia

A. L. Bulteau et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

Review Biochemistry & Molecular Biology

Mammalian iron metabolism and its control by iron regulatory proteins

Cole P. Anderson et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Article Biochemistry & Molecular Biology

The yeast metacaspase is implicated in oxidative stress response in frataxin-deficient cells

Sophie Lefevre et al.

FEBS LETTERS (2012)

Article Clinical Neurology

Clinical Features of Friedreich Ataxia

Martin B. Delatycki et al.

JOURNAL OF CHILD NEUROLOGY (2012)

Article Biochemistry & Molecular Biology

The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity

Catrine Johansson et al.

BIOCHEMICAL JOURNAL (2011)

Article Cardiac & Cardiovascular Systems

Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2

Zoltan Ungvari et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)

Article Biochemistry & Molecular Biology

Characterization of the human monothiol glutaredoxin 3 (PICOT) as iron-sulfur protein

Petra Haunhorst et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Article Biochemistry & Molecular Biology

Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets

Anton A. Turanov et al.

BIOCHEMICAL JOURNAL (2010)

Article Biochemistry & Molecular Biology

Human Iron-Sulfur Cluster Assembly, Cellular Iron Homeostasis, and Disease

Hong Ye et al.

BIOCHEMISTRY (2010)

Article Biochemistry & Molecular Biology

trans-Resveratrol downregulates Txnip overexpression occurring during liver ischemia-reperfusion

Valerie Nivet-Antoine et al.

BIOCHIMIE (2010)

Article Biochemistry & Molecular Biology

Altered lipid metabolism in a Drosophila model of Friedreich's ataxia

Juan A. Navarro et al.

HUMAN MOLECULAR GENETICS (2010)

Article Biochemistry & Molecular Biology

Both Thioredoxin 2 and Glutaredoxin 2 Contribute to the Reduction of the Mitochondrial 2-Cys Peroxiredoxin Prx3

Eva-Maria Hanschmann et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Clinical Neurology

The dorsal root ganglion in Friedreich's ataxia

Arnulf H. Koeppen et al.

ACTA NEUROPATHOLOGICA (2009)

Article Biochemistry & Molecular Biology

Frataxin deficiency induces Schwann cell inflammation and death

Chunye Lu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)

Article Clinical Neurology

Complex I and ATP Content Deficiency in Lymphocytes from Friedreich's Ataxia

Mohammad Mehdi Heidari et al.

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES (2009)

Article Clinical Neurology

Friedreich ataxia: The clinical picture

Massimo Pandolfo

JOURNAL OF NEUROLOGY (2009)

Article Multidisciplinary Sciences

Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant

Michael Li-Hsuan Huang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress

Viviana I. Perez et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Article Biochemistry & Molecular Biology

Glutathione-dependent redox status of frataxin-deficient cells in a yeast model of Friedreich's ataxia

Francoise Auchere et al.

HUMAN MOLECULAR GENETICS (2008)

Article Clinical Neurology

Antioxidant use in Friedreich ataxia

Lauren Myers et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2008)

Article Clinical Neurology

The dentate nucleus in Friedreich's ataxia: the role of iron-responsive proteins

Arnulf H. Koeppen et al.

ACTA NEUROPATHOLOGICA (2007)

Article Biochemistry & Molecular Biology

Glutathione is recruited into the nucleus in early phases of cell proliferation

Jelena Markovic et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Oxidative stress and protease dysfunction in the yeast model of Friedreich ataxia

Anne-Laure Bulteau et al.

FREE RADICAL BIOLOGY AND MEDICINE (2007)

Article Biochemistry & Molecular Biology

Causative role of oxidative stress in a Drosophila model of Friedreich ataxia

Jose V. Llorens et al.

FASEB JOURNAL (2007)

Article Biochemistry & Molecular Biology

How does iron-sulfur cluster coordination regulate the activity of human glutaredoxin 2?

Carsten Berndt et al.

ANTIOXIDANTS & REDOX SIGNALING (2007)

Article Biochemistry & Molecular Biology

Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase

Mahesh Thirunavukkarasu et al.

FREE RADICAL BIOLOGY AND MEDICINE (2007)

Article Biochemistry & Molecular Biology

Nitric oxide induces thioredoxin-1 nuclear translocation: Possible association with the p21Ras survival pathway

Roberto J. Arai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Review Biochemistry & Molecular Biology

Molecular control of vertebrate iron homeostasis by iron regulatory proteins

Michelle L. Wallander et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2006)

Article Biochemistry & Molecular Biology

Thiol redox control via thioredoxin and glutaredoxin systems

A Holmgren et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2005)

Article Multidisciplinary Sciences

Characterization of human glutaredoxin 2 as iron-sulfur protein:: A possible role as redox sensor

CH Lillig et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Overexpression of glutaredoxin 2 attenuates apoptosis by preventing cytochrome c release

M Enoksson et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Article Clinical Neurology

Friedreich ataxia in carriers of unstable borderline GAA triplet-repeat alleles

R Sharma et al.

ANNALS OF NEUROLOGY (2004)

Article Biochemistry & Molecular Biology

Frataxin-mediated iron delivery to ferrochelatase in the final step of heme biosynthesis

T Yoon et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Biochemistry & Molecular Biology

Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles

K Itoh et al.

FREE RADICAL BIOLOGY AND MEDICINE (2004)

Article Biochemistry & Molecular Biology

Glutaredoxin is essential for maintenance of brain mitochondrial complex I: studies with MPTP

RS Kenchappa et al.

FASEB JOURNAL (2003)

Article Biochemistry & Molecular Biology

Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis

T Tanaka et al.

EMBO JOURNAL (2002)

Article Cell Biology

Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes

MT Rodríguez-Manzaneque et al.

MOLECULAR BIOLOGY OF THE CELL (2002)

Article Biochemistry & Molecular Biology

Thioredoxin reductase reduces lipid hydroperoxides and spares α-tocopherol

JM May et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)

Article Biochemistry & Molecular Biology

Manganese superoxide dismutase induction by iron is impaired in Friedreich ataxia cells

S Jiralerspong et al.

FEBS LETTERS (2001)

Article Medicine, General & Internal

Glutathione in blood of patients with Friedreich's ataxia

F Piemonte et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2001)

Article Biochemistry & Molecular Biology

Disabled early recruitment of antioxidant defenses in Friedreich's ataxia

K Chantrel-Groussard et al.

HUMAN MOLECULAR GENETICS (2001)

Article Biochemistry & Molecular Biology

Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2

VN Gladyshev et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms

M Lundberg et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Review Biochemistry & Molecular Biology

Antioxidant Function of Thioredoxin and Glutaredoxin Systems

Arne Holmgren

ANTIOXIDANTS & REDOX SIGNALING (2000)

Article Biochemistry & Molecular Biology

Nucleoredoxin, glutaredoxin, and thioredoxin differentially regulate NF-κB, AP-1, and CREB activation in HEK293 cells

K Hirota et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)

Article Biochemistry & Molecular Biology

Transcriptional regulation of glutaredoxin and thioredoxin pathways and related enzymes in response to oxidative stress

MJ Prieto-Alamo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Biochemistry & Molecular Biology

Clinical, biochemical and molecular genetic correlations in Friedreich's ataxia

JL Bradley et al.

HUMAN MOLECULAR GENETICS (2000)