Journal
ANTIOXIDANTS
Volume 9, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/antiox9121212
Keywords
oxidative stress; protein carbonylation; lipid peroxidation; hematological malignancies
Funding
- Instituto de Investigacion Hospital 12 de Octubre (i +12)
- CRIS Foundation
- Ministry of Science, Innovation and Universities of Spain Government [FPU19/04933]
- Spanish Society of Hematology and Hemotherapy (SEHH)
- Asociacion Espanola contra el Cancer (AECC)
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Among the different mechanisms involved in oxidative stress, protein carbonylation and lipid peroxidation are both important modifications associated with the pathogenesis of several diseases, including cancer. Hematopoietic cells are particularly vulnerable to oxidative damage, as the excessive production of reactive oxygen species and associated lipid peroxidation suppress self-renewal and induce DNA damage and genomic instability, which can trigger malignancy. A richer understanding of the clinical effects of oxidative stress might improve the prognosis of these diseases and inform therapeutic strategies. The most common protein carbonylation and lipid peroxidation compounds, including hydroxynonenal, malondialdehyde, and advanced oxidation protein products, have been investigated for their potential effect on hematopoietic cells in several studies. In this review, we focus on the most important protein carbonylation and lipid peroxidation biomarkers in hematological malignancies, their role in disease development, and potential treatment implications.
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