Journal
BIOMOLECULES
Volume 10, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/biom10111557
Keywords
ubiquitin-like protein (UBL); ISG15 and ISGylation; UBA7 (UBEL1); EFP (TRIM25) and HERC5; USP18 (UBP43); DNA damage response (DDR); genome stability; p53 family members; DNA replication fork progression and translesion synthesis
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Funding
- BBSRC AstraZeneca collaborative training partnership (CTP) studentship
- University of Manchester President's Doctoral Scholar award
- BBSRC David Phillips Fellowship [BB/N019997/1]
- BBSRC [BB/N019997/1] Funding Source: UKRI
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Maintenance of genome stability is a crucial priority for any organism. To meet this priority, robust signalling networks exist to facilitate error-free DNA replication and repair. These signalling cascades are subject to various regulatory post-translational modifications that range from simple additions of chemical moieties to the conjugation of ubiquitin-like proteins (UBLs). Interferon Stimulated Gene 15 (ISG15) is one such UBL. While classically thought of as a component of antiviral immunity, ISG15 has recently emerged as a regulator of genome stability, with key roles in the DNA damage response (DDR) to modulate p53 signalling and error-free DNA replication. Additional proteomic analyses and cancer-focused studies hint at wider-reaching, uncharacterised functions for ISG15 in genome stability. We review these recent discoveries and highlight future perspectives to increase our understanding of this multifaceted UBL in health and disease.
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