Journal
BIOMOLECULES
Volume 11, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/biom11010060
Keywords
ubiquitin– proteasome system; proteostasis; immunity; autoinflammation; cancer
Categories
Funding
- German Research Foundation [SFB/Transregio 167]
- Comprehensive Cancer Center Mecklenburg-Vorpommern (CCC-MV)
- DFG (German Research Foundation) [393148499]
- Open Access Publication Fund of the University of Greifswald
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The ubiquitin-proteasome system (UPS) is a crucial protein degradation system in cells, particularly impacting immune cells and their rapid functional remodeling during immune activation. Recent research has shed light on the molecular mechanisms by which UPS contributes to immune responses and its role in immune disorders like cancer and auto-inflammatory diseases.
The ubiquitin-proteasome system (UPS) is the major intracellular and non-lysosomal protein degradation system. Thanks to its unique capacity of eliminating old, damaged, misfolded, and/or regulatory proteins in a highly specific manner, the UPS is virtually involved in almost all aspects of eukaryotic life. The critical importance of the UPS is particularly visible in immune cells which undergo a rapid and profound functional remodelling upon pathogen recognition. Innate and/or adaptive immune activation is indeed characterized by a number of substantial changes impacting various cellular processes including protein homeostasis, signal transduction, cell proliferation, and antigen processing which are all tightly regulated by the UPS. In this review, we summarize and discuss recent progress in our understanding of the molecular mechanisms by which the UPS contributes to the generation of an adequate immune response. In this regard, we also discuss the consequences of UPS dysfunction and its role in the pathogenesis of recently described immune disorders including cancer and auto-inflammatory diseases.
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