Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2020.630754
Keywords
TET2; epigenetic; epitranscriptomic; pluripotency; reprogramming; development; 5hmC
Categories
Funding
- Spanish Agencia Estatal de Investigacion
- FEDER Program of the EU [RTI2018-096708-J-I00, BFU2016-80899-P, PID2019-105739GB-I00]
- 2020 Leonardo Grant for Researchers and Cultural Creators BBVA Foundation
- Xunta de GaliciaConselleria de Cultura, Educacion e Ordenacion Universitaria [ED431F 2016/016]
- European Commission [MSCA-IF-EF-RI-895984]
- Ramon y Cajal awards [RYC-2014-16779]
- Ministerio de Ciencia, Innovacion y Universidades [FPU17/01131]
- Xunta de Galicia [ED481A-2020/187]
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TET2 plays a crucial role in cell fate outcomes by catalyzing demethylation on DNA and potentially through RNA hydroxymethylation. It influences transcriptional regulation, normal development, and pluripotency contexts, showcasing its versatility in genome regulation and cellular phenotypes.
Ten-eleven translocation-2 (TET2) is a crucial driver of cell fate outcomes in a myriad of biological processes, including embryonic development and tissue homeostasis. TET2 catalyzes the demethylation of 5-methylcytosine on DNA, affecting transcriptional regulation. New exciting research has provided evidence for TET2 catalytic activity in post-transcriptional regulation through RNA hydroxymethylation. Here we review the current understanding of TET2 functions on both DNA and RNA, and the influence of these chemical modifications in normal development and pluripotency contexts, highlighting TET2 versatility in influencing genome regulation and cellular phenotypes.
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