Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2020.603837
Keywords
amino acids (AAs); metabolism; cancer; mTORC (mammalian target of rapamycin kinase complex); epigenetic; tumor immunity; ferroptosis; tumor growth
Categories
Funding
- National Natural Science Foundation of China [81902668, 31771545, 91749120, 31821002]
- Yubei District Science and Technology Commission of Chongqing [2020-36]
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Metabolic reprogramming involving amino acid metabolism is a recognized hallmark of malignancy, with potential therapeutic implications in targeting this pathway for cancer treatment. Amino acids play a crucial role in supporting survival and proliferation of cancer cells under various stress conditions.
Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The uptake and metabolism of amino acids are aberrantly upregulated in many cancers that display addiction to particular amino acids. Amino acids facilitate the survival and proliferation of cancer cells under genotoxic, oxidative, and nutritional stress. Thus, targeting amino acid metabolism is becoming a potential therapeutic strategy for cancer patients. In this review, we will systematically summarize the recent progress of amino acid metabolism in malignancy and discuss their interconnection with mammalian target of rapamycin complex 1 (mTORC1) signaling, epigenetic modification, tumor growth and immunity, and ferroptosis. Finally, we will highlight the potential therapeutic applications.
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