Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2020.602269
Keywords
angiogenesis; vascular niche; inflammation; bone metastasis; arthritis; bone marrow microenvironment
Categories
Funding
- Medical Research Council [CDA: MR/P02209X/1]
- European Research Council [805201, 2017/JGF/001]
- Royal Society [RG170326]
- Kennedy Trust for Rheumatology Research [KENN 15 16 09]
- John Fell Fund OUP Research Fund [161/061]
- UKRI Future Leaders Fellow [S016538]
- Centre for Osteoarthritis Pathogenesis Versus Arthritis [20205, 21621]
- NIHR Oxford Biomedical Research Centre
- European Research Council (ERC) [805201] Funding Source: European Research Council (ERC)
- MRC [MR/P02209X/1] Funding Source: UKRI
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The bone marrow (BM) vascular niche microenvironments harbor stem and progenitor cells of various lineages. Bone angiogenesis is distinct and involves tissue-specific signals. The nurturing vascular niches in the BM are complex and heterogenous consisting of distinct vascular and perivascular cell types that provide crucial signals for the maintenance of stem and progenitor cells. Growing evidence suggests that the BM niche is highly sensitive to stress. Aging, inflammation and other stress factors induce changes in BM niche cells and their crosstalk with tissue cells leading to perturbed hematopoiesis, bone angiogenesis and bone formation. Defining vascular niche remodeling under stress conditions will improve our understanding of the BM vascular niche and its role in homeostasis and disease. Therefore, this review provides an overview of the current understanding of the BM vascular niches for hematopoietic stem cells and their malfunction during aging, bone loss diseases, arthritis and metastasis.
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