Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2020.607038
Keywords
adipokines; actomyosin; calcium; actin; epithelium
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Funding
- Academy of Finland
- University of Helsinki
- Sigrid Juselius Foundation
- Jane and Aatos Erkko Foundation
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Obesity is a major risk factor for the development of breast cancer in postmenopausal women, with the adipokine leptin strongly linked to tumor cell proliferation and metastasis. Leptin activates leptin receptors and mechanosensitive Ca2+ channels to regulate actomyosin dynamics, thus playing a role in the development of breast carcinomas.
In postmenopausal women, a major risk factor for the development of breast cancer is obesity. In particular, the adipose tissue-derived adipokine leptin has been strongly linked to tumor cell proliferation, migration, and metastasis, but the underlying mechanisms remain unclear. Here we show that treatment of normal mammary epithelial cells with leptin induces EMT-like features characterized by higher cellular migration speeds, loss of structural ordering of 3D-mammo spheres, and enhancement of epithelial traction forces. Mechanistically, leptin triggers the phosphorylation of myosin light chain kinase-2 (MLC-2) through the interdependent activity of leptin receptor and Ca2+ channels. These data provide evidence that leptin-activated leptin receptors, in co-operation with mechanosensitive Ca2+ channels, play a role in the development of breast carcinomas through the regulation of actomyosin dynamics.
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