Journal
NATURE REVIEWS CHEMISTRY
Volume 5, Issue 1, Pages 46-61Publisher
NATURE RESEARCH
DOI: 10.1038/s41570-020-00233-6
Keywords
-
Categories
Funding
- Royal Society University Research Fellowship
Ask authors/readers for more resources
This review discusses the development of stimuli-responsive supramolecular systems for controlling ion transport, signal transduction, and catalysis in lipid bilayer membrane systems. Recent progress in achieving spatio-temporal control over activity in artificial and living cells is highlighted in the article. Challenges, scope, limitations, and future potential for using supramolecular systems to engineer stimuli-responsive lipid bilayer membranes are also discussed.
The membrane proteins found in nature control many important cellular functions, including signal transduction and transmembrane ion transport, and these, in turn, are regulated by external stimuli, such as small molecules, membrane potential and light. Membrane proteins also find technological applications in fields ranging from optogenetics to synthetic biology. Synthetic supramolecular analogues have emerged as a complementary method to engineer functional membranes. This Review describes stimuli-responsive supramolecular systems developed for the control of ion transport, signal transduction and catalysis in lipid-bilayer-membrane systems. Recent advances towards achieving spatio-temporal control over activity in artificial and living cells are highlighted. Current challenges, the scope, limitations and future potential to exploit supramolecular systems for engineering stimuli-responsive lipid-bilayer membranes are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available