Journal
NATURE BIOMEDICAL ENGINEERING
Volume 5, Issue 10, Pages 1143-1156Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41551-020-00673-x
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Funding
- State Key Research Development Programme of China [2016YFC1103000, 2018YFC1106400]
- National Natural Science Foundation of China [51433007, 51673125, 51773127, 51873115, 51803131, 51803134]
- Science and Technology Program of Sichuan Province [2017SZ0011, 2019YJ0132]
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Council of Canada (NSERC)
- Michael Smith Foundation for Health Research Career Scholar Award
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Hydrogel microspheres adsorbing coagulation factors can provide transient blood-thinning in extracorporeal circulation, promoting faster recovery of hemostasis and potentially increasing the safety of clinical blood-purification procedures.
During extracorporeal blood purification, anticoagulants are administered to prevent thrombogenesis. However, haemorrhagic complications owing to near-complete inactivation of blood coagulation and delayed recovery of haemostasis pose serious risks to patients. Here, we show in vitro and in beagle dogs that hydrogel microspheres that adsorb the coagulation factors VIII, IX and XI provide transient blood thinning when placed in the extracorporeal circuit before blood purification. The microspheres inhibited the activities of the coagulation factors by levels (similar to 8-30%) similar to those occurring in mild haemophilia. On its reintroduction into the animal, the purified pseudo-haemophilic blood favoured faster recovery of haemostasis. The transient blood-thinning strategy may increase the safety of clinical blood-purification procedures.
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