Journal
FOOD SCIENCE & NUTRITION
Volume 9, Issue 1, Pages 459-468Publisher
WILEY
DOI: 10.1002/fsn3.2014
Keywords
AMPK signaling pathway; Chlorella pyrenoidosa; ethanol extract; hypolipidemic; lipid metabolism
Categories
Funding
- Fujian Agriculture and Forestry University International Cooperation Project [KXG15001A]
- 13th FiveYear Plan Ocean Economy Innovation and Development Demonstration City Project [FZHJ17]
- Xiamen City Marine and Fisheries Development Special Fund [18CYY026HJ13]
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The 95% ethanol extract of Chlorella pyrenoidosa (CPE95) was found to increase serum high-density lipoprotein cholesterol content while decreasing cholesterol, triglyceride, and low-density lipoprotein cholesterol levels in hyperlipidemic rats. Additionally, CPE95 alleviated liver fat accumulation and deformation, and downregulated the expression of several lipid metabolism-related genes, indicating its potential to effectively improve hyperlipidemia.
The aim of this study was to explore the effects and mechanisms of 95% ethanol extract of Chlorella pyrenoidosa (CPE95) on lipid metabolism in hyperlipidemic rats. For the sake of chemical composition analysis of CPE95, liquid chromatography-mass spectrometry (LC-MS) was used for determination. After treatment with CPE95, serum high-density lipoprotein cholesterol content of the hyperlipidemic rats was increased, while the contents of cholesterol, triglyceride, and low-density lipoprotein cholesterol were decreased strikingly. Moreover, the result of histopathology analysis showed that the accumulation and fatty deformation of the livers were relieved. Real-time quantitative PCR and Western blotting were used to determine the expression levels of lipid metabolism-related genes. The gene expression level of adenosine 5'-monophosphate-activated protein kinase was descended, and expressions of sterol regulatory element-binding protein-1c, acetyl-CoA carboxylase, and 3-hydroxy-3-methylglutaryl coenzyme A reductase were all downregulated in the CPE95-treated rats. It suggested that CPE95 may effectively improve the hyperlipidemia in rats and would be potential for functional food component to reduce blood lipid.
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