Journal
ELECTROANALYSIS
Volume 28, Issue 11, Pages 2697-2702Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201600140
Keywords
Albendazole; Gold electrode; Electrochemical Reduction; LC-MS
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Funding
- Rowan University, Department of Chemistry
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Albendazole (ABZ) is a widely used anthelmintic drug for the treatment of parasitic worms and other diseases. The bulk electrolysis reduction reaction of albendazole (ABZ) was carried out in ammonium bromide-acetonitrile solution under stirring conditions. The reduction of albendazole at gold electrode gave three non-reversible waves. The average value of the electron transfer coefficient (n) was found to be 0.505. The measured diffusion coefficient (D) had a value of 0.143x10(-8)cm(2)s(-1). The bulk electrochemical reduction of ABZ products were characterized using liquid chromatography-mass spectroscopy. Three cyclic voltammetry reduction waves were observed using a gold electrode and three chromatographic peaks were observed using liquid chromatography- Mass spectrometry. The observed results suggested that the second and third reduction steps occurred at the sulfur functional group of albendazole.
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