Journal
PHARMACEUTICS
Volume 12, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics12121208
Keywords
nanocomposite thin films; layer-by-layer assembly; strength; Young's modulus; toughness; pH-responsive drug release; cell viability
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Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs) and anilinated-poly (ether ether ketone) (AN-PEEK) have synthesized, and AN-PEEK/f-CNOs composite thin films were primed via layer-by-layer (LbL) self-assembly for stimuli-responsive drug release. The obtained thin films exhibited pH-responsive drug release in a controlled manner; pH 4.5 = 99.2% and pH 6.5 = 59.3% of doxorubicin (DOX) release was observed over 15 days. Supramolecular pi-pi stacking interactions between f-CNOs and DOX played a critical role in controlling drug release from thin films. Cell viability was studied with human osteoblast cells and augmented viability was perceived. Moreover, the thin films presented 891.4 +/- 8.2 MPa of the tensile strength (sigma(ult)), 43.2 +/- 1.1 GPa of Young's modulus (E), and 164.5 +/- 1.7 Jg(-1) of toughness (K). Quantitative scrutiny revealed that the well-ordered aligned nanofibers provide critical interphase, and this could be responsible for augmented tensile properties. Nonetheless, a pH-responsive and mechanically robust biocompatible thin-film system may show potential applications in the biomedical field.
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