Journal
FRONTIERS IN ONCOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2020.562950
Keywords
sirtuin4; cancer; structure; localization; enzymatic activities; metabolism; mitochondria
Categories
Funding
- National Natural Science Foundation of China [81672428, 81872427, 81703000]
- Applied Technology Research and Development Program of Heilongjiang Province [GA19C002]
- Fundamental Research Funds for the Provincial Universities of Heilongjiang Province
- Excellent Discipline Construction Program (Hepatobiliary and Pancreatic Tumor 2017) [Nn10]
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Sirtuins are a conserved family of protein lysine deacylases, with SIRT4 playing a crucial role in mitochondria and various biological processes such as energy metabolism, oxidative stress, and aging. It also has an impact on tumorigenesis.
Sirtuins (SIRTs) are members of the silent information regulator-2 family. They are a conserved family of nicotinamide adenine dinucleotide-dependent protein lysine deacylases. SIRTS are involved in intricate cellular processes. There are seven subtypes of SIRTs (1-7) in mammals. SIRT4 is located mainly in mitochondria and has various catalytic activities. These enzyme activities give it a diverse range of important biologic functions, such as energy metabolism, oxidative stress, and aging. Cancer is characterized as reprogramming of energy metabolism and redox imbalance, and SIRT4 can affect tumorigenesis. Here, we review the structure, localization, and enzyme activity of SIRT4 and its role in various neoplasms.
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