TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner

Previous studies have revealed that TIPE1 serves as a tumor suppressor gene in several tumor types. However, we demonstrated that TIPE1 can promote cervical cancer proliferation by suppressing p53 activity. Here, we showed that TIPE1 inhibits cervical cancer cell apoptosis both in vivo and in vitro. Mechanistically, we revealed that TIPE1 facilitates chemoresistance in a wild-type p53-dependent manner. The results indicated that TIPE1 is responsible for the transition from chemosensitivity to chemoresistance, and that it can serve as a promising target in cervical cancer chemotherapy.

Automated summary

Previous studies have shown that TIPE1 acts as a tumor suppressor gene in several tumor types, but in cervical cancer, it promotes proliferation by inhibiting p53 activity, suppressing cell apoptosis, and facilitating chemoresistance in a p53-dependent manner. This suggests that TIPE1 plays a crucial role in the transition from chemosensitivity to chemoresistance and could be a potential target for cervical cancer chemotherapy.